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生物源
rabbit
品質等級
100
500
共軛
unconjugated
抗體表格
culture supernatant
抗體產品種類
primary antibodies
無性繁殖
SP16, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (108R-14)
vial of 0.5 mL concentrate (108R-15)
bottle of 1.0 mL predilute (108R-17)
vial of 1.0 mL concentrate (108R-16)
bottle of 7.0 mL predilute (108R-18)
製造商／商標名
Cell Marque™
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同型
IgG1
控制
tonsil
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
membranous
基因資訊
human ... CD8A(925)
一般說明
Anti-CD8 is a T-cell marker for the detection of cytotoxic/suppressor lymphocytes. CD8 is also detected on NK cells, most thymocytes, a subpopulation of null cells and bone marrow cells. This antibody, along with other markers, can be used to distinguish between reactive and neoplastic T-cells. Expression of both CD4 (+) and CD8 (+), or lack of expression of both markers in a lymphoid population would be evidence for lymphoma. Although most T-cell lymphoma/leukemias can be either CD8+ or CD8-, CD8 positivity is a factor against Mycosis Fungoides as this entity is negative for CD8. Rarely does anti-CD8 label non-hematolymphoid neoplasms.
聯結
CD8 Positive Control Slides, Product No. 108S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
準備報告
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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V Bakels et al.
The American journal of pathology, 150(6), 1941-1949 (1997-06-01)
Differentiation between cutaneous pseudo-T-cell lymphomas and cutaneous T-cell lymphomas (CTCLs) may be extremely difficult. In this study, it was investigated whether demonstration of an aberrant phenotype and detection of clonal T-cell receptor gamma (TCR gamma) gene rearrangements can be used
Peiguo G Chu et al.
American journal of clinical pathology, 120(1), 64-70 (2003-07-18)
We studied the expression of CD2, CD3, CD4, CD5, CD7, CD8, CD56, and CD138 in 447 cases of common human neoplasms with epithelioid features. CD2, CD3, CD4, and CD8 antigens were detected in none of 447 cases of nonhematopoietic tumors.
Reactive Lymphadenopathies
Chan J, Tsang W
Pathology of Lymph Nodes, Churchill Livingstone, 81-167 (1996)
Diagnostic Immunohistochemistry: Theranostic and Genomic Applications (2006)
G Gaidano et al.
Leukemia, 14(4), 563-566 (2000-04-14)
In recent times, the field of B cell lymphoma histogenesis has progressed rapidly due to the increasing availability of histogenetic markers. Genotypic markers of B cell histogenesis are represented by mutations of IgV and BCL-6 genes, which are somatically acquired
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