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Merck

P0510000

己酮可可碱

European Pharmacopoeia (EP) Reference Standard

别名:

3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental

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About This Item

经验公式(希尔记法):
C13H18N4O3
CAS号:
分子量:
278.31
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

pentoxifylline

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

SMILES 字串

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

InChI 密鑰

MQGNNJQTNFHNHK-UHFFFAOYSA-N

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Pentoxifylline EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Lact.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Alejandro Bravo-Cuellar et al.
Journal of biomedical science, 20, 13-13 (2013-03-01)
In Oncology, the resistance of the cancerous cells to chemotherapy continues to be the principal limitation. The nuclear factor-kappa B (NF-κB) transcription factor plays an important role in tumor escape and resistance to chemotherapy and this factor regulates several pathways
Cheng-Chung Fang et al.
PloS one, 7(9), e44765-e44765 (2012-10-03)
Excessive fibrin deposition in the peritoneum is thought to be involved in the development of encapsulating peritoneal sclerosis (EPS), an important cause of morbidity and mortality in peritoneal dialysis patients. We investigated fibrin-induced epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells
Umair Sohail et al.
Clinics in liver disease, 16(4), 717-736 (2012-10-30)
Alcoholic hepatitis is a form of severe, cholestatic liver disease that results from consumption of large amount of alcohol during a sustained period of time in a subset of alcoholics. Symptoms could be mild and nonspecific to more severe. The diagnosis
Saad Hamama et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 105(3), 305-312 (2012-10-02)
Radiation-induced fibrosis is a serious late complication of radiotherapy. Pentoxifylline-vitamin E has proven effective and safe in clinical trials in the treatment of fibrosis, while the molecular mechanism of its activity is yet unexplored. Ten patients suffering from radiation-induced enteropathy
Simone Appenzeller et al.
Rheumatology international, 31(11), 1511-1513 (2009-12-17)
Behcet's disease is an inflammatory disorder of unknown cause, characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. All these common manifestations are self-limiting except for the ocular attacks. The objective of the present study is to

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