M1900000

咪康唑

European Pharmacopoeia (EP) Reference Standard

• 别名: （±）-咪康唑 硝酸盐, 1-（2,4-二氯-β-[（2,4-二氯苄基）氧] 苯乙基 ] 咪唑
• 经验公式（希尔记法）: C₁₈H₁₄Cl₄N₂O · HNO₃
• CAS号: 22832-87-7
• 分子量: 479.14
• MDL號碼: MFCD00058161
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329817922
• NACRES: NA.24

属性

• 等級: pharmaceutical primary standard
• API 家族: miconazole
• 製造商／商標名: EDQM
• 應用: pharmaceutical (small molecule)
• 格式: neat
• SMILES 字串: ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
• InChI: 1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
• InChI 密鑰: MCCACAIVAXEFAL-UHFFFAOYSA-N

说明

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Miconazole nitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化／生理作用

咪康唑与 14-α 相互作用脱甲基酶，一种麦角固醇生物合成所必需的细胞色素 P-450 酶。麦角固醇的抑制导致细胞通透性增加引起细胞内容物渗漏。咪康唑还可能抑制内源性呼吸，与细胞膜中的磷脂相互作用，抑制酵母菌转化为菌丝形式，抑制嘌呤摄取，干扰甘油三酯和磷脂的生物合成。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H317
• 防範說明: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• 危險分類: Acute Tox. 4 Oral - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable