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C5901

Supelco

可待因 一水合物

analytical standard

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About This Item

经验公式（希尔记法）:
C18H21NO3 · H2O
CAS号:
6059-47-8
分子量:
317.38
MDL號碼:
MFCD01940504
分類程式碼代碼:
41116107
PubChem物質ID:
329775106
NACRES:
NA.24

等級

analytical standard

品質等級

200

agency

EPA 1694

藥物控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

clinical testing

格式

neat

儲存溫度

2-8°C

SMILES 字串

CN1[C@H](C2)[C@@]3([H])[C@@]4(CC1)C5=C2C=CC(OC)=C5O[C@@]4([H])[C@@H](O)C=C3.O

InChI

1S/C18H21NO3.H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;/h3-6,11-13,17,20H,7-9H2,1-2H3;1H2/t11-,12+,13-,17-,18-;/m0./s1

InChI 密鑰

WRRSFOZOETZUPG-FFHNEAJVSA-N

基因資訊

human ... CYP2D6(1565) , OPRD1(4985) , OPRK1(4986) , OPRM1(4988)
rat ... Cyp2d1(266684) , Cyp2d2(25053) , Cyp2d3(24303) , Cyp2d4v1(171522)

相关类别

應用

Codeine monohydrate has been used as a standard in the quantitative analysis of codeine by using different types of protein assays like biuret, bicinchoninic acid (BCA), coomassie brilliant blue (CBB) , pyrogallol red–molybdate (PRM) assay, Lowry assay and benzethonium chloride (BEC) assay, while relating the effective response of the drug with the type of assay.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生化／生理作用

弱麻醉性镇痛剂，作用机理可能是由于可转化成吗啡，其催眠作用较弱；强效镇咳剂

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
SLBP3955V
SLBM7029V
SLBH9849V
SLBF7351V
SLBD2068V

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An evaluation of protein assays for quantitative determination of drugs.
Williams K M, et al.
Journal of Biochemical and Biophysical Methods, 57(1), 45-55 (2003)
K Krause et al.
Allergy, 68(2), 256-258 (2013-01-17)
Platelet-activating factor (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hypothesis that PAF-induced wheal development is secondary to histamine release from dermal mast cells. But is this hypothesis correct? Wheal and flare responses
Codeine phosphate in paediatric medicine.
D G Williams et al.
British journal of anaesthesia, 86(3), 413-421 (2001-09-28)
Parvaz Madadi et al.
Pharmacogenomics, 9(9), 1267-1284 (2008-09-11)
Codeine has been used medicinally since the 1800s as an analgesic and antitussive agent. Although very few studies have methodically examined the safety of codeine use in the pediatric age group, it is nonetheless commonly prescribed to children and breastfeeding
Marieke Nauta et al.
American journal of surgery, 198(2), 256-261 (2009-07-25)
Cesarean section, episiotomy, and third and perineal tears are associated with significant tissue damage, causing pain in the immediate postpartum period. The current standard in North America is to prescribe oral acetaminophen/codeine (A + C) for postpartum pain. Codeine has
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