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描述
N-methyl-N-deacetyl-colchicine
品質等級
無菌
sterile; 0.2 μm filtered
形狀
solution
包裝
pkg of 20 mL (10 μg/ml)
製造商／商標名
Roche
技術
blocking: suitable
雜質
microbial, tested
溶解度
water: miscible
儲存溫度
2-8°C
SMILES 字串
CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13
InChI
1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
InChI 密鑰
NNJPGOLRFBJNIW-HNNXBMFYSA-N
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一般說明
秋水仙胺也被称为地美辛星。它的通用名称是 N-甲基-N-去乙酰秋水仙碱。秋水仙胺可解聚微管并在中期阻断有丝分裂。
應用
秋水仙碱可抑制有丝分裂纺锤体的形成。它可用于增加染色体分析中中期细胞的百分比。
生化／生理作用
通常在核型分析和细胞周期研究中，其可在细胞周期的特定阶段增加有丝分裂细胞的产量。这可以通过多种方式来实现，其中最流行的是使用细胞周期同步剂，例如地美考辛。地美考辛会将细胞停滞于中期，同时对有丝分裂细胞或经同步的G1和S期细胞中的生化事件无明显影响。经常会用地美可辛处理白细胞以阻止中期细胞。
外觀
溶液（10 μg/ml），已通过0.2 μm孔径滤膜过滤。
其他說明
仅用于生命科学研究。不用于诊断操作。
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
does not flash
閃點（°C）
does not flash
其他客户在看
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Cloning and stem cells, 11(1), 141-152 (2009-02-20)
This study aimed to evaluate the effect of demecolcine, a microtubule-depolymerizing agent, on microtubule kinetics; to determine the best concentration of demecolcine as a chemically assisted enucleation agent in metaphase I (MI) and metaphase II (MII) bovine oocytes, and to
Vasiliki Tasiou et al.
PloS one, 10(8), e0134672-e0134672 (2015-08-15)
The human RB1 gene is imprinted due to integration of the PPP1R26P1 pseudogene into intron 2. PPP1R26P1 harbors the gametic differentially methylated region of the RB1 gene, CpG85, which is methylated in the female germ line. The paternally unmethylated CpG85
Candice L Wike et al.
eLife, 5, e11402-e11402 (2016-02-18)
Phosphorylation of histone H3 threonine 118 (H3 T118ph) weakens histone DNA-contacts, disrupting the nucleosome structure. We show that Aurora-A mediated H3 T118ph occurs at pericentromeres and chromosome arms during prophase and is lost upon chromosome alignment. Expression of H3 T118E
Roshan L Shrestha et al.
The Journal of cell biology, 220(4) (2021-02-24)
Chromosomal instability (CIN) is a hallmark of many cancers. Restricting the localization of centromeric histone H3 variant CENP-A to centromeres prevents CIN. CENP-A overexpression (OE) and mislocalization have been observed in cancers and correlate with poor prognosis; however, the molecular
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