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生物源
human
品質等級
包裝
vial of 500 μg
製造商／商標名
Millipore
技術
cell culture | stem cell: suitable
運輸包裝
dry ice
儲存溫度
−20°C
應用
The relationship between polyamine systems and cancer---as well as critical normal cell processes--- led to the creation of clickable polyamine derivatives which are innovative and novel tools for functional studies of the polyamine transport system (PTS). Spermidine and other important polyamine derivatives were conjugated to a BODIPY fluorophore through click chemistry.
MW: 599.44 g/mol
SPECTRAL PROPERTIES
λex: 494 nm
λem: 508 nm
MW: 599.44 g/mol
SPECTRAL PROPERTIES
λex: 494 nm
λem: 508 nm
特點和優勢
The BioTracker Clickable Polyamine Spermidine Live Cell Probe is click-conjugated to a green fluorophore to enable the study of polyamine tracking with superior cellular uptake. Probe may be dissolved in DMSO to make a 10mM stock solution. 1 uL of a 10 mM stock solution may be added to 1 mL media to produce a 10 uM working solution. Add probe/media solution to washed cells and incubate at 37C for up to 4h.
標靶描述
Polyamines play a variety of critical roles in the cell. Some of these processes include gene expression, cell proliferation and differentiation, and cellular stress management.
Polyamine dysregulation is key in a variety of cancers. In colorectal cancer, polyamine content and biosynthesis is significantly higher when compared to normal colorectal tissue. A relationship between polyamines and their metabolites has been used to observe progression in cancers of the breast, lung, colorectal system, ovary, prostate, and pancreas.
In normal cells, there is tight regulation of polyamines through normal cellular mechanisms. One of these is the polyamine transport system (PTS). The characteristics of the PTS are not fully understood, but study of the PTS has shown that many cancer cells have high PTS activity, suggesting this system as a promising target for cancer research.
Polyamine dysregulation is key in a variety of cancers. In colorectal cancer, polyamine content and biosynthesis is significantly higher when compared to normal colorectal tissue. A relationship between polyamines and their metabolites has been used to observe progression in cancers of the breast, lung, colorectal system, ovary, prostate, and pancreas.
In normal cells, there is tight regulation of polyamines through normal cellular mechanisms. One of these is the polyamine transport system (PTS). The characteristics of the PTS are not fully understood, but study of the PTS has shown that many cancer cells have high PTS activity, suggesting this system as a promising target for cancer research.
儲存和穩定性
Store at -20 °C, protected from light
其他說明
This spermidine derivative click-conjugated to BODIPY is optimized for the study of the polyamine transport system, which is exploited in diverse cancers.
法律資訊
BioTracker is a trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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