SCT092

BioTracker PyrPeg Amyloid-b Live Cell Dye

• 别名: BioTracker PyrPeg Amyloid-b Live Cell Dye
• 分類程式碼代碼: 12352207
• NACRES: NA.47

属性

• 形狀: lyophilized
• 分子量: calculated mol wt 459.49
• 包裝: pkg of 1 mg
• 製造商／商標名: Millipore
• 儲存條件: protect from light
• 增長模式: N/A
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

Alzheimer′s disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (Aβ) plagues and neurofibrillary tangles. The accumulation of Aβ plaques is an early event in the pathogenesis of AD. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. BioTracker PyrPeg Amyloid-b Live Cell Dye is a two-photon fluorescent probe that specifically detects insoluble Aβ, rather than tau and alpha-synuclein aggregates (1). This probe may serve as a useful blood-brain-barrier penetrating tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the AD model brain (1).Reference:1. Choi, Ji-Woo, et al. "PyrPeg, a Blood–Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates." ACS Chemical Neuroscience 11.12 (2020): 1801-1810.

應用

Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.

特點和優勢

Two-photon fluorescent probe for imaging insoluble forms of Amyloid-beta aggregates in Alzheimer′s disease studies.

外觀

Lyophilized. Orange solid.

儲存和穩定性

Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable