SCT059
BioTracker TiY Vimentin Live Cell Dye
Live cell imaging probe for identifying tumor initiating cells (TICs) in a variety of epithelial cancers, including lung cancer. The TiY probe binds to vimentin expressed in TICs.
别名:
Live cell imaging probe, Tumor Initiating Cell (TIC) dye
登录查看公司和协议定价
所有图片(2)
About This Item
分類程式碼代碼:
12352207
NACRES:
NA.47
推荐产品
化驗
≥98% (H-NMR)
≥98% (HPLC)
≥98% (LC/MS)
≥98% (elemental analysis)
技術
cell based assay: suitable
檢測方法
fluorometric
一般說明
Vimentin is an intermediate filament protein which is upregulated in cells undergoing epithelial-to-mesenchymal transition (EMT), and hence is commonly used an EMT marker. Tumor initiating cells (TICs) have been implicated in clinical relapse and metastasis of a variety of epithelial cancers, including lung cancer.
BioTracker TiY Vimentin is a live cell fluorescent dye that selectively stains TICs over differentiated tumor cells or normal cells. TiY can be used for visualization and enrichment of functionally active TICs from patient tumors. TiY displays better selectivity for tumorigenic cells than a CD166 antibody and can be used for TiY-staining-based cell sorting for TICs in various types of cancer (lung, CNS, melanoma, breast, renal, ovarian, colon and prostate cancer). At high concentrations, TiY shows selective anti-TIC activity over non-TIC and normal tissue cells.
Spectral Properties
Absorbance: 553 nm
Emission: 573 nm
References
Lee Y et al. Identification of Tumor Initiating Cells with a Small-Molecule Fluorescent Probe by Using Vimentin as a Biomarker. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2851-2854.
BioTracker TiY Vimentin is a live cell fluorescent dye that selectively stains TICs over differentiated tumor cells or normal cells. TiY can be used for visualization and enrichment of functionally active TICs from patient tumors. TiY displays better selectivity for tumorigenic cells than a CD166 antibody and can be used for TiY-staining-based cell sorting for TICs in various types of cancer (lung, CNS, melanoma, breast, renal, ovarian, colon and prostate cancer). At high concentrations, TiY shows selective anti-TIC activity over non-TIC and normal tissue cells.
Spectral Properties
Absorbance: 553 nm
Emission: 573 nm
References
Lee Y et al. Identification of Tumor Initiating Cells with a Small-Molecule Fluorescent Probe by Using Vimentin as a Biomarker. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2851-2854.
應用
Live cell fluorescent imaging
Live cell imaging probe for identifying tumor initiating cells (TICs) in a variety of epithelial cancers, including lung cancer. The TiY probe binds to vimentin expressed in TICs.
Research Category
Cell Imaging
Cell Imaging
Research Sub Category
Live Cell Dye
Live Cell Dye
品質
Purity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 541.87 g/mol
Molar Mass: 541.87 g/mol
外觀
Lyophilized
儲存和穩定性
Store BioTracker TiY Vimentin Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
其他說明
Concentration: Please refer to lot specific datasheet.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门