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一般說明
QKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients.
特異性
This antibody demonstrates cross reactivity against QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of California, Davis.).
免疫原
Recombinant protein corresponding to human Pan-QKI.
應用
Anti-Pan-QKI Antibody, clone N147/6 is a highly specific mouse monoclonal antibody & that targets QKI & has been tested in western blotting.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pan-QKI in human frontal cortex.
Immunohistochemistry Analysis: A representative lot detected Pan-QKI in rat hippocampus tissue (Prof. J. Trimmer, University of California, Davis.).
Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of rat brain tissue.
Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of mouse brain membrane tissue.
Western Blotting Analysis: A representative lot detected Pan-QKI in RBM cell lysates and in COS cell lysates transfected with QKI-5, QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of Califorina, Davis.).
Immunohistochemistry Analysis: A representative lot detected Pan-QKI in rat hippocampus tissue (Prof. J. Trimmer, University of California, Davis.).
Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of rat brain tissue.
Western Blotting Analysis: 2 µg/mL from a representative lot detected Pan-QKI in 10 µg of mouse brain membrane tissue.
Western Blotting Analysis: A representative lot detected Pan-QKI in RBM cell lysates and in COS cell lysates transfected with QKI-5, QKI-6, QKI-7, and QKI-7b (Prof. J. Trimmer, University of Califorina, Davis.).
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
品質
Evaluated by Western Blotting in rat brain membrane tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected Pan-QKI in 10 µg of rat brain membrane tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected Pan-QKI in 10 µg of rat brain membrane tissue lysate.
標靶描述
~36-40 kDa observed. Uniprot describes six isoforms observed between 35-38 kDa Uncharacterized band(s) may be observed in some cell lysates.
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
Rat brain membrane tissue lysate.
Rat brain membrane tissue lysate.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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