MABN1583

Anti-CALML5 Antibody, clone 3F6.1

clone 3F6.1, from mouse

• 别名: Calmodulin-like protein 5, Calmodulin-like skin protein
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 3F6.1, monoclonal
• 物種活性: human
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG2aκ
• NCBI登錄號: NP_059118
• UniProt登錄號: Q9NZT1
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CALML5(51806)

说明

一般說明

Calmodulin-like protein 5 (UniProt Q9NZT1; also known as Calmodulin-like skin protein) is encoded by the CALML5 (also known as CLSP) gene (Gene ID 51806) in human. Epidermal differentiation and barrier function depend on many calcium-regulated proteins and enzymes. CALML5/CLSP is expressed in the stratum granulosum and lower layers of the stratum corneum of the skin, where it modulates the function of calcium-dependent proteins, such as transglutaminase 3. CALML5/CLSP level is upregulated in granular and spinal keratinocytes during the later stages of wound healing in human epidermis and eventually returns to basal level once the wound is closed and barrier function has been restored. In the hyperproliferative skin disorders psoriasis and atopic dermatitis (AD), the permeability barrier is disturbed, causing an increased CLSP built-up as a result of decresed CLSP degradation due to an altered calcium gradient.

特異性

Clone 3F6.1 recognizes an epitope outside the first EF-hand motif.

免疫原

Epitope: Outside the first EF-hand motif.

GST-tagged recombinant human CALML5 lacking the first EF-hand motif.

應用

Anti-CALML5 Antibody, clone 3F6.1 is an antibody against CALM5 for use in Western Blotting, Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CALML5 in human tonsil and skin tissue sections.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

品質

Evaluated by Western Blotting of human CALML5 GST fusion protein.

Western Blotting Analysis: 0.05 µg/mL of this antibody detected 0.05 µg of human CALML5 GST fusion protein.

標靶描述

15.89 kDa calculated. Uncharacterized band(s) may appear in some lysates.

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable