生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
OX-108, monoclonal
分子量
calculated mol wt 36.60 kDa
純化經由
using protein G
物種活性
human
包裝
antibody small pack of 100
技術
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
inhibition assay: suitable
surface plasmon resonance (SPR): suitable
同型
IgG1κ
表位序列
Extracellular domain
Protein ID登錄號
UniProt登錄號
儲存溫度
-10 to -25°C
基因資訊
human ... CD200R1(131450)
特異性
Clone OX-108 is a mouse monoclonal antibody that detects CD200R. It targets an epitope within the extracellular domain.
免疫原
Full-length, recombinant human CD200R.
應用
Quality Control Testing
Evaluated by Flow Cytometry with human peripheral blood mononuclear cells (PBMCs).
Flow Cytometry Analysis: 1.0 µg from a representative lot detected CD200R in one million human peripheral blood mononuclear cells (PBMCs).
Tested Applications
Surface Plasmon Resonance: A representative lot detected CD200R in surface plasmon resonance application (Hatherley, D., et al. (2004). Eur J Immunol. 34(6):1688-94).
Immunohistochemistry Application: A representative lot detected CD200R in immunohistochemistry application (Koning, N., et al. (2009). J Neuropathol Exp Neurol. 68(2):159-67).
Inhibition: A representative lot blocked ligand-receptor interactions in protein microarray application (Letarte, M., et al. (2005). BMC Biochem.1:6:2).
Flow Cytometry Analysis: A representative lot detected CD200R in flow cytometry application (Wright, G.J., et al. (2003). J Immunol. 171(6):3034-46; Foster-Cuevas, M., et al. (2004). J Virol. 78(14):7667-76; Koning, N., et al. (2009). J Neuropathol Exp Neurol. 68(2):159-67).
Immunofluorescence Analysis: A representative lot detected CD200R in immunofluorescence application (Letarte, M., et al. (2005). BMC Biochem.1:6:2).
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
Evaluated by Flow Cytometry with human peripheral blood mononuclear cells (PBMCs).
Flow Cytometry Analysis: 1.0 µg from a representative lot detected CD200R in one million human peripheral blood mononuclear cells (PBMCs).
Tested Applications
Surface Plasmon Resonance: A representative lot detected CD200R in surface plasmon resonance application (Hatherley, D., et al. (2004). Eur J Immunol. 34(6):1688-94).
Immunohistochemistry Application: A representative lot detected CD200R in immunohistochemistry application (Koning, N., et al. (2009). J Neuropathol Exp Neurol. 68(2):159-67).
Inhibition: A representative lot blocked ligand-receptor interactions in protein microarray application (Letarte, M., et al. (2005). BMC Biochem.1:6:2).
Flow Cytometry Analysis: A representative lot detected CD200R in flow cytometry application (Wright, G.J., et al. (2003). J Immunol. 171(6):3034-46; Foster-Cuevas, M., et al. (2004). J Virol. 78(14):7667-76; Koning, N., et al. (2009). J Neuropathol Exp Neurol. 68(2):159-67).
Immunofluorescence Analysis: A representative lot detected CD200R in immunofluorescence application (Letarte, M., et al. (2005). BMC Biochem.1:6:2).
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
標靶描述
Cell surface glycoprotein CD200 receptor 1 (UniProt: Q8TD46; also known as CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1) is encoded by the CD200R1 (also known as CD200R, CRTR2, MOX2R, OX2R, UNQ2522/PRO6015) gene (Gene ID: 131450) in human. CD200R is an inhibitory receptor that plays a crucial role in the regulation of immune responses. It is primarily involved in maintaining immune homeostasis by delivering inhibitory signals that downregulate inflammatory responses and prevent overactivation of the immune system. Upon binding with its ligand, CD200, CD200R transduces signals that inhibit the activation of macrophages, dendritic cells, and other immune cells, thereby promoting tolerance and preventing autoimmune reactions. CD200R is expressed on various immune cells, including macrophages, dendritic cells, neutrophils, and certain subsets of T cells and B cells. It is also found on some non-immune cells, such as neurons and endothelial cells. The expression of CD200R1 is generally upregulated in response to inflammatory stimuli and during certain stages of immune cell differentiation. CD200R is implicated in various autoimmune diseases, cancer, infectious and neurodegenerative diseases.
外觀
Purified mouse monoclonal antibody IgG1 in PBS without azide.
重構
0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
儲存和穩定性
Store at -10°C to -25°C. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门