推荐产品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
DT9, monoclonal
物種活性
human
技術
flow cytometry: suitable
immunoprecipitation (IP): suitable
同型
IgG2bκ
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... HLA-C(3107)
一般說明
HLA-C, also known as HLA class I histocompatibility antigen, Cw-1 alpha chain, also known as MHC class I antigen Cw*1, and encoded by the gene HLA-C/HLAC. It contains an alpha and beta (beta-2-microglobulin) chain and interacts with the human herpesvirus 8 MIR1 protein.
The previously assigned protein identifier P30499 has been merged into P10321. Full details can be found on the UniProt database.
The previously assigned protein identifier P30499 has been merged into P10321. Full details can be found on the UniProt database.
免疫原
Purified tamarin MHC class I molecules corresponding to human HLA-C.
應用
Anti-HLA-C Antibody, clone DT9 is an antibody against HLA-C for use in flow cytometry & IP.
Flow Cytometry Analysis: A representative lot from an independent laboratory detected HLA-C in peripheral blood CD3+ cells from 200 healthy human donors (Apps, R., et al. (2013). Science. 340(6128):84-91.).
Flow Cytometry Analysis: A representative lot from an independent laboratory detected HLA-C in human PBMCs (Corrah, T. W., et al. (2011). J Virol. 85(7):3367-3374.).
Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated HLA-C from various human cell lines (Braud, V. M., et al. (1998). Curr Biol. 8(1):1-10.).
Flow Cytometry Analysis: A representative lot from an independent laboratory detected HLA-C in human PBMCs (Corrah, T. W., et al. (2011). J Virol. 85(7):3367-3374.).
Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated HLA-C from various human cell lines (Braud, V. M., et al. (1998). Curr Biol. 8(1):1-10.).
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Inflammation & Autoimmune Mechanisms
Inflammation & Autoimmune Mechanisms
品質
Evaluated by Flow Cytometry in human PBMCs.
Flow Cytometry Analysis: 1 µg of this antibody detected HLA-C in 1X10E6 human PBMCs.
Flow Cytometry Analysis: 1 µg of this antibody detected HLA-C in 1X10E6 human PBMCs.
標靶描述
41 kDa calculated
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Tumena W Corrah et al.
Journal of virology, 85(7), 3367-3374 (2011-01-21)
Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can
V M Braud et al.
Current biology : CB, 8(1), 1-10 (1998-03-28)
The human major histocompatibility complex (MHC) class lb molecule HLA-E is transcribed in most tissues but little is known about its localisation within the cell. We have recently shown that HLA-E binds signal-sequence-derived peptides from human MHC class I molecules
Kristina Hopfensperger et al.
mBio, 11(4) (2020-07-16)
HLA-C-mediated antigen presentation induces the killing of human immunodeficiency virus (HIV)-infected CD4+ T cells by cytotoxic T lymphocytes (CTLs). To evade killing, many HIV-1 group M strains decrease HLA-C surface levels using their accessory protein Vpu. However, some HIV-1 group
Richard Apps et al.
Science (New York, N.Y.), 340(6128), 87-91 (2013-04-06)
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of
Eri Yamada et al.
Cell host & microbe, 23(1), 110-120 (2018-01-13)
The HIV-1-encoded accessory protein Vpu exerts several immunomodulatory functions, including counteraction of the host restriction factor tetherin, downmodulation of CD4, and inhibition of NF-κB activity to facilitate HIV-1 infection. However, the relative contribution of individual Vpu functions to HIV-1 infection
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