MABD116

Anti-Dux4 Antibody, clone 9A12

clone 9A12, from mouse

• 别名: double homeobox protein 4, Double homeobox protein 10, Double homeobox protein 4/10, Dux-4
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 9A12, monoclonal
• 物種活性: human
• 技術: electrophoretic mobility shift assay: suitable; immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• 同型: IgG1κ
• NCBI登錄號: NP_149418
• UniProt登錄號: Q9UBX2
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... DUX4(100288687)

说明

一般說明

Dux4 is a homeodomain protein with a similar protein sequence to Pax3 and Pax7. Defects in Dux4 may be the cause of facioscapulohumeral muscular dystrophy (FSHD). FSHD is characterized by weakness of the muscles of the face, upper-arm and shoulder girdle. Ectopic expression of Dux4 in skeletal muscle activates the expression of stem cell and germline genes, and, when overexpressed in somatic cells, Dux4 can ultimately lead to cell death.

免疫原

Epitope: domain of: C-Terminal region

recombinant protein corresponding to the domain of: C-Terminal region of Human Dux4.

應用

Detect Dux4 using this mouse monoclonal antibody, Anti-Dux4 Antibody, clone 9A12 validated for use in western blotting, ICC, Electrophoretic Mobility Shift Assay & IP.

Research Category
Stem Cell Research

Stem Cell Research

Research Sub Category
Muscle Physiology

Developmental Signaling

This antibody has been shown to work in immunocytochemistry applications (Dixit et al. 2007). This antibody has been shown to work in electrophoretic mobility shift assays (Dixit et al. 2007). This antibody has been shown to work in immunoprecipitation applications (Anseau et al., 2009).

品質

Evaluated by Western Blot in a human skeletal muscle tissue lysate. Western Blot Analysis: A 1:250 dilution of this antibody detected Dux4 in a human skeletal muscle tissue lysate.

標靶描述

~58 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human skeletal muscle tissue lysate.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable