MABC291
Anti-PSMA Antibody, clone 3/A12
clone 3/A12, from mouse
别名:
Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic
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About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
3/A12, monoclonal
物種活性
human
技術
activity assay: suitable
flow cytometry: suitable
immunofluorescence: suitable
inhibition assay: suitable
western blot: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... FOLH1(2346)
一般說明
Prostate-specific membrane antigen (PSMA), also known as Glutamate carboxypeptidase II (GCPII), Folate hydrolase 1 (FOLH1), and N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I), is a member of the peptidase M28 family and is involved in prostate tumor progression. It is highly expressed in prostate epithelium and detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, and brain (at protein level). Mutations in PSMA have been associated with prostate cancer and hyperhomocysteinemia. PSMA may be a possible marker for neurological disorders such as schizophrenia, Alzheimer′s disease, and Huntington disease.
免疫原
Recombinant protein corresponding to human PSMA.
應用
Anti-PSMA Antibody, clone 3/A12 is a highly specific mouse monoclonal antibody, that targets PSMA & has been tested in Flow Cytometry, western blotting, Immunofluorescence, Activity Assay & Inhibition.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Western Blotting Analysis: A representative lot from an independent laboratory detected purified PSMA in WB (Elsasser-Beile, U., et al. (2006). Prostate. 66(13):1359-1370.).
Immunofluorescence Analysis: A representative lot from an independent laboratory detected PSMA in LNCaP cells (Elsasser-Beile, U., et al. (2006). Prostate. 66(13):1359-1370.).
Inhibition Assay Analysis (Small-animal PET imaging): A representative lot from an independent laboratory blocked PSMA in mice bearing PSMA-positive C4-2 tumors and negative DU145 tumors (Elsasser-Beile, U., et al. (2009). J Nucl Med. 50(4):606-611.).
Activity Assay Analysis: A representative lot from an independent laboratory was co-internalized with cell adherent PSMA, when PSMA binds to its putative ligand (Liu, J. et al. (2009). Mol Pharm. 6(3):959-970.).
Immunofluorescence Analysis: A representative lot from an independent laboratory detected PSMA in LNCaP cells (Elsasser-Beile, U., et al. (2006). Prostate. 66(13):1359-1370.).
Inhibition Assay Analysis (Small-animal PET imaging): A representative lot from an independent laboratory blocked PSMA in mice bearing PSMA-positive C4-2 tumors and negative DU145 tumors (Elsasser-Beile, U., et al. (2009). J Nucl Med. 50(4):606-611.).
Activity Assay Analysis: A representative lot from an independent laboratory was co-internalized with cell adherent PSMA, when PSMA binds to its putative ligand (Liu, J. et al. (2009). Mol Pharm. 6(3):959-970.).
品質
Evaluated by Flow Cytometry in 1X10E6 LNCaP cells.
Flow Cytometry Analysis: 1 µg of this antibody detected PSMA in LNCaP cells.
Flow Cytometry Analysis: 1 µg of this antibody detected PSMA in LNCaP cells.
標靶描述
84 kDa calculated
聯結
Replaces: MABN1035
外觀
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
PET imaging of prostate cancer xenografts with a highly specific antibody against the prostate-specific membrane antigen.
Elsasser-Beile, Ursula, et al.
Journal of Nuclear Medicine, 50, 606-611 (2009)
A new generation of monoclonal and recombinant antibodies against cell-adherent prostate specific membrane antigen for diagnostic and therapeutic targeting of prostate cancer.
Elsasser-Beile, Ursula, et al.
Prostate, 66, 1359-1370 (2006)
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