推荐产品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
8211, monoclonal
物種活性
human
製造商／商標名
Chemicon®
技術
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... NTF3(4908)
一般說明
The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells.
特異性
Reacts with NGF-receptors in human system.
免疫原
Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983).
應用
Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 is an antibody against Nerve Growth Factor Receptor (p75) for use in IC, IH, IH(P) & WB.
Immunohistochemistry: 5-10 μg/mL
Immunocytochemistry: 5-10 μg/mL
Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf
Western Blot: 1ug/mL
Immunoabsorptive purification of NGF-receptors
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 5-10 μg/mL
Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf
Western Blot: 1ug/mL
Immunoabsorptive purification of NGF-receptors
Optimal working dilutions must be determined by end user.
標靶描述
75 kDa
聯結
Replaces: 04-1111
外觀
Format: Purified
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nerve growth factor receptor immunohistochemistry has a limited additional value to diagnose Hirschsprung\'s disease.
Granstrom AL, Orrego A, Svensson PJ, Almstrom M, Skikuniene J, Wester T
Pediatric Surgery International null
Production and characterization of monoclonal antibodies against human malignant melanoma.
Herlyn, M, et al.
Cancer Investigation, 1, 215-224 (1983)
Nerve growth factor is mitogenic for cancerous but not normal human breast epithelial cells.
Descamps, S, et al.
The Journal of Biological Chemistry, 273, 16659-16662 (1998)
F Hefti et al.
Annals of neurology, 20(3), 275-281 (1986-09-01)
Alzheimer's disease is associated with a pronounced loss of the cholinergic neurons that form the ascending cholinergic projections of the basal forebrain. Even though the disease is also characterized by changes in other neuronal systems and by a high frequency
Darren Carwardine et al.
PloS one, 12(12), e0188967-e0188967 (2017-12-12)
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix
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