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Merck
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Key Documents

MAB2259Z

Sigma-Aldrich

Anti-Integrin β1 Antibody, activated, clone B44, azide free

clone B44, Chemicon®, from mouse

别名:

Ligand-inducedBindingSite, LIBS, CLIBS, MAB2259

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

B44, monoclonal

物種活性

human

製造商/商標名

Chemicon®

技術

cell culture | mammalian: suitable
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同型

IgG1

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... ITGB1(3688)

特異性

Detects a cation- and ligand-induced binding site (LIBS) of integrin beta 1, which has been used in some systems as a reporter of integrin functionality.

應用

Immunoprecipitation of detergent-solubilized (1 integrins: 2-4 μg/IP

Western blot: 10-15 μg/mL

Flow Cytometry: 10-15 μg/mL

Immunohistochemistry

Stimulation of (1-mediated adhesion: 10-20 μg/mL.

Optimal working dilutions must be determined by end user.
This Anti-Integrin β1 Antibody, activated, clone B44, azide free is validated for use in FC, IH, IP, FUNC, CULT, WB for the detection of Integrin β1.

標靶描述

88 kDa

外觀

Format: Purified
Purified immunoglobulin. Liquid PBS, containing no preservatives.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Induction of type XVI collagen expression facilitates proliferation of oral cancer cells.
Sabine Ratzinger,Susanne Grassel,Albert Dowejko,Torsten E Reichert,Richard J Bauer
Matrix Biology null
Are changes in integrin affinity and conformation overemphasized? REVIEW
Bazzoni G. and Hemler M.
Trends in Biochemical Sciences, 23, 30-34 (1998)
M Levite et al.
The Journal of experimental medicine, 191(7), 1167-1176 (2000-04-05)
Elevated extracellular K(+) ([K(+)](o)), in the absence of "classical" immunological stimulatory signals, was found to itself be a sufficient stimulus to activate T cell beta1 integrin moieties, and to induce integrin-mediated adhesion and migration. Gating of T cell voltage-gated K(+)
Weisheng Wang et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(11), 2723-2732 (2016-06-09)
Estradiol (E2) perfusion rapidly increases the strength of fast excitatory transmission and facilitates long-term potentiation in the hippocampus, two effects likely related to its memory-enhancing properties. Past studies showed that E2's facilitation of transmission involves activation of RhoA signaling leading
Tommy Hui et al.
Matrix biology : journal of the International Society for Matrix Biology, 41, 19-25 (2014-12-03)
Osteopontin (OPN) is a ligand for the α4ß1 integrin, but the physiological importance of this binding is not well understood. Here, we have assessed the effect of post-translational modifications on OPN binding to the α4 integrin on cultured human leukocyte

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