生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
SAP, monoclonal
物種活性
human
製造商／商標名
Chemicon®
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... ITGB3(3690)
特異性
Monoclonal antibody MAB2008 is specific for the beta-3 subunit of the vitronectin receptor (VNR)J, which is expressed on endothelial cells, platelets, melanoma, and glioma cells. The antibody is of high affinity.
免疫原
Membranes of freshly isolated human platelets.
應用
Detect Integrin β3 using this Anti-Integrin β3 Antibody, clone SAP validated for use in WB, IH, IH(P).
Immunohistochemistry (frozen and fixed tissue sections) including paraffin embedded sections. {See Van Belle et al 1999, original paper detailing the use in human, paraffin tissues}
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10333228.
Western blot: recognizes ~115kDa band in reduced
Optimal working dilutions must be determined by end user.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10333228.
Western blot: recognizes ~115kDa band in reduced
Optimal working dilutions must be determined by end user.
外觀
Format: Purified
Purified immunoglobulin. Liquid at 1 mg/mL in 0.02M phosphate buffer, 0.25M sodium chloride, pH 7.6, containing 0.1% sodium azide as a preservative.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer.
Jin Ju Kim,Jong-Tae Kim,Hyo Ran Yoon,Min Ah Kang,Joo Heon Kim,Young-Ha Lee,Jae Wha Kim et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine null
G Gruber et al.
British journal of cancer, 92(1), 41-46 (2004-12-15)
Integrins are cell-surface receptors, which mediate cell-to-cell and cell-to-extracellular matrix adhesion. Besides playing an important role in tumour angiogenesis, beta3-integrin is also expressed in several types of epithelial cancer cells. It was the purpose of the present study to evaluate
Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells.
Yan-Xi Sun,Ming Fang,Jianhua Wang,Carlton R Cooper,Kenneth J Pienta,Russell S Taichman
Prostate null
P A Van Belle et al.
Human pathology, 30(5), 562-567 (1999-05-20)
The expression of the beta3 integrin subunit was investigated in 130 fixed, paraffin-embedded specimens of human melanomas and nevi using two different monoclonal antibodies. Expression was not observed in melanocytes and was absent or low in most nevi. In primary
Renée DuQuesnay et al.
Fertility and sterility, 91(2), 489-499 (2008-03-21)
To characterize possible endometrial defects in infertile women with isolated PCO morphology. Prospective study. An academic hospital with an IVF unit. Women with primary unexplained infertility and isolated PCO, fertile women, and women with infertility secondary to male factor. Thirty-one
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