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HNABTMAG-68K

Millipore

MILLIPLEX® 人淀粉样蛋白β和Tau磁珠板 - 多重分析

allows quantitative multiplex detection of multiple analytes simultaneously

别名:

Human Neuroscience Protein Multiplex Assay, Luminex® Human Neuroscience Panel, Millipore Human Neuroscience Immunoassay

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About This Item

分類程式碼代碼:
12161503
eCl@ss:
32161000
NACRES:
NA.84

品質等級

物種活性

human

製造商/商標名

Milliplex®

assay range

accuracy: 109%
(Spike recovery for Aβ1-42)

accuracy: 91%
(Spike recovery for pTau181)

accuracy: 98%
(Spike recovery for tTau)

sensitivity: 1.5 pg/mL
(pTau181; MinDC+2SD)

sensitivity: 10.2 pg/mL
(A?1-40; MinDC+2SD)

sensitivity: 14.2 pg/mL
(tTau; MinDC+2SD)

sensitivity: 2.5 pg/mL
(A?1-42; MinDC+2SD)

standard curve range: 0.7-500 pg/mL
(pTau181)

standard curve range: 11-8000 pg/mL
(tTau)

standard curve range: 2-2000 pg/mL
(Aβ1-42)

standard curve range: 21-15000 pg/mL
(Aβ1-40)

inter-assay cv: <15%
intra-assay cv: <10%

技術

multiplexing: suitable

檢測方法

fluorometric (Luminex xMAP)

運輸包裝

wet ice

一般說明

MILLIPLEX®人类β淀粉样蛋白和Tau蛋白面板使您能够专注于研究模型中Aβ40、Aβ42、总Tau蛋白(tTau)和磷酸化Tau Thr181(pTau181)的相关性和治疗潜力。结合微珠格式的Luminex® xMAP®平台,您可以获得理想的速度和灵敏度,允许同时对多个分析物进行定量多重检测,从而可以显著提高生产率。

MILLIPLEX®人淀粉样蛋白βTau珠面板将用于同时定量Aβ40,Aβ42,tTau和pTau181。本试剂盒仅可用于脑脊液(CSF)分析。这是一种可配置的检测试剂盒,可以选择一些或全部分析物:tau(总)、淀粉样蛋白β40、淀粉样蛋白β42和tau(pThr181)。

MILLIPLEX®产品组合可在广泛的疾病状态和物种中提供最广泛的分析物选择。一旦确定了目标分析物,您就可以依靠我们在每个试剂盒中构建的质量来产生您可以信赖的结果。除方案中列出的检测特征外,验证过程中评价的其他性能标准包括:交叉反应性、稀释线性、试剂盒稳定性和样品行为(例如,可检测性和稳定性)。每个样本组和试剂盒均符合严格的生产标准,以确保批间可再现性。

每个MILLIPLEX®检测板和试剂盒包括:
•提供质量控制(QC)以确认检测性能
•将标准品(校准品)和QC批次与参考批次进行比较,以确保批间一致性
•优化血清基质以模拟天然分析物环境
•检测抗体混合物设计用于在检测板内产生一致的分析物谱

MILLIPLEX®人类淀粉样蛋白βTau珠面板是可用于细胞因子研究的最通用系统的一部分。从单一到多重生物标记物溶液,我们与您合作,设计、开发、分析验证和建立可用于蛋白质检测和定量的最全面的库。

面板类型:神经科学

特異性

交叉反应性
对于面板中的一种分析物和任何其他分析物,抗体之间没有或有可以忽略不计的交叉反应性。

應用

  • 分析物:Tau(总计),淀粉样蛋白β40,淀粉样蛋白β42,Tau(pThr181)
  • 推荐的样品类型:脑脊液(CSF)
  • 推荐的样品稀释度:建议对提取的CSF样本进行1:2样品稀释
  • 分析运行时间:过夜
  • 研究类别:神经科学代谢
  • 研究亚类: 代谢紊乱肥胖炎症&自身免疫机制
  • 研究类别神经科学代谢
  • 注:这是竞争性测定。

特點和優勢

通过在此面板中选择可用的分析物来设计多重试剂盒。

包裝

96孔培养板
单个试剂盒即可满足您的所有需求。

成分

人ABeta和Tau标准品,1个小瓶,冻干

人ABeta和Tau质量控制1,1个小瓶,冻干

人ABeta和Tau质量控制2,1个小瓶,冻干

微珠稀释剂,1瓶,3.5 mL

一组96孔板,含2个密封剂

分析缓冲液,1瓶,30 mL

洗涤缓冲液,10X(0.05%Proclin),2瓶,30 mL ea

人ABeta和Tau检测抗体,1瓶,3.2 mL

链霉亲和素-藻红蛋白,1瓶,3.2 mL

混合瓶,1瓶

儲存和穩定性

试剂盒组分建议的存储温度为2-8°C。

法律資訊

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

象形圖

Skull and crossbonesEnvironment

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects


分析证书(COA)

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Jessica L Hoffman et al.
International review of neurobiology, 148, 169-230 (2019-11-18)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the most common cause of dementia in the United States. Although the link between alcohol use and AD has been studied, preclinical research has potential to elucidate neurobiological mechanisms that
Mohamed Raâfet Ben Khedher et al.
Alzheimer's & dementia (New York, N. Y.), 7(1), e12124-e12124 (2021-02-05)
In brain, extracellular vesicles (EVs) play an essential role in the neuron-glia interface and ensure the crosstalk between the brain and the periphery. Some studies now link the pathway dysfunction of the EVs to apolipoprotein E gene variant (APOE ε4)
Wencheng Yin et al.
Frontiers in neuroscience, 14, 602642-602642 (2021-01-05)
Alzheimer's disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and neurological decline are still unclear. Here we combine genome-wide transcriptional
Grace E Weber et al.
Journal of immunology (Baltimore, Md. : 1950), 204(5), 1111-1118 (2020-01-22)
Individuals with Down syndrome (DS) develop Alzheimer's disease (AD)-related neuropathology, characterized by amyloid plaques with amyloid β (Aβ) and neurofibrillary tangles with tau accumulation. Peripheral inflammation and the innate immune response are elevated in DS. Triggering receptor expressed in myeloid
Charbel Moussa et al.
Journal of neuroinflammation, 14(1), 1-1 (2017-01-15)
Treatment of mild-moderate Alzheimer's disease (AD) subjects (N = 119) for 52 weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates progressive declines in CSF Aβ40 levels and activities of daily living (ADL) scores. For this retrospective study

实验方案

A stem cell culture protocol to generate 3D NSC models of Alzheimer’s disease using ReNcell human neural stem cell lines.

相关内容

Learn how to integrate multiplex and high sensitivity immunoassay technology to further neuroscience research with MILLIPLEX® multiplex and Single Molecule Counting (SMC®) high sensitivity immunoassay detection of Alzheimer’s disease (AD) biomarkers in human cerebrospinal fluid, plasma, and serum samples.

Neuroscience multiplex assays, such as MILLIPLEX® multiplex assays, enable simultaneous measurement of neuroscience-related biomarkers to gain a better picture of neurodegenerative diseases, neurological disorders, and neuropeptide/neurohormone signaling.

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