GF092

TRAIL蛋白，重组人类

Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called APO2 Ligand, is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells.

• 别名: Apo2 Ligand
• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.75

属性

• 生物源: human
• 品質等級: 100
• 重組細胞: expressed in E. coli
• 化驗: >98% (SDS-PAGE and HPLC)
• 形狀: solid
• 分子量: 19.6 kDa
• 製造商／商標名: Chemicon^®
• 技術: cell culture | mammalian: suitable
• 雜質: <0.1 ng/μg Endotoxin (of TRAIL/Apo2L; 1EU/μg)
• 輸入: sample type hematopoietic stem cell(s)
• 適合性: suitable for molecular biology
• NCBI登錄號: NM_003810.2
• UniProt登錄號: P50591
• 運輸包裝: dry ice
• 基因資訊: human ... TNFSF10(8743)

说明

一般說明

Research area: CancerTNF-Related Apoptosis-Inducing Ligand (TRAIL) is a cytotoxic and type II membrane protein. It belongs to the tumor necrosis factor (TNF) superfamily. TRAIL is expressed by the cells of the immune system including natural killer cells, macrophages, T cells, and dendritic cells. TRAIL Protein, Recombinant human is a 19.6 kDa protein

應用

TRAIL Protein, Recombinant human has been used as anapoptosis inducer: to extract cell-free DNA (cfDNA) from various cell linesalong with BV6 to study its anticancer effects in breast cancer cell lines, tostudy its effects of ethanol-induced interferon expression on TRAIL release in neurons

生化／生理作用

TNF-Related Apoptosis-Inducing Ligand (TRAIL) promotes rapid apoptosis in tumor cells while sparing normal cells. Thisproperty of TRAIL makes it an important biotherapeutic agent in cancer therapy.It induces apoptosis by binding to two death signaling receptors, DR4 and DR5expressed on cell membranes.

外觀

无菌过滤，然后从 0.3 mg/mL（含 10mM 磷酸钠 + 110mM NaCl）溶液中冻干。

儲存和穩定性

冻干的蛋白可以在室温下保存数周，但最好在 -20°C 下保存。 快速离心后，在无菌水中重新配制至 0.5-1.0 mg/mL。 可以将该溶液稀释到其他缓冲溶液中，并在 4ºC 下保存 1 周或 -20ºC 以备将来使用。 自收到之日起，重悬的 GF092 应该以未稀释的等分试样在 -20°C 下保存长达 6 个月。应避免反复冻/融循环。

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3