ABT143

Anti-L1CAM Antibody

from rabbit, purified by affinity chromatography

• 别名: Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human, rat
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI登錄號: NP_076493
• UniProt登錄號: P32004
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... L1CAM(3897)

说明

一般說明

Families of adhesion molecules which share common carbohydrate domains do exist, despite the structural and functional diversity of these glycoproteins. These include the Ca2+-independent neural adhesion molecules (N-CAM), myelin associated glycoprotein (MAG) and L1. L1 is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts.

特異性

This antibody recognizes the extracellular domain of L1CAM in addition antibody recognizes the full length form (~220 kDa) and the cleaved form (~140 kDa) of L1CAM.

免疫原

Epitope: Extracellular domain

GST-tagged recombinant protein corresponding to the extracellular domain of human L1CAM.

應用

Anti-L1CAM Antibody is a highly specific rabbit polyclonal antibody, that targets Neural cell adhesion molecule L1 & has been tested in western blotting & IHC (Paraffin).

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

Western Blotting Analysis: 0.4 µg/mL from a representative lot detected L1CAM in 10 µg of rat brain tissue lysate.
Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected L1CAM in human kidney and human cerebellum tissue.

品質

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 0.4 µg/mL of this antibody detected L1CAM in 10 µg of human brain tissue lysate.

標靶描述

~220 / 140 kDa observed. The full length protein and the cleaved form of L1CAM have been observed at ~220 kDa and ~140 kDa, respectively (Kalus, I., et al. (2003). The Journal of Biological Chemistry. 278(12):10381-10388). Uncharacterized band(s) may appear in some lysates.

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Human brain tissue lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable