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Merck
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主要文件

AB3841

Sigma-Aldrich

Anti-Connexin 43 Antibody, phospho-specific (Ser368)

Chemicon®, from rabbit

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
無性繁殖:
polyclonal
application:
WB
物種活性:
hamster, mouse, rat, monkey, human
技術:
western blot: suitable
citations:
3

生物源

rabbit

品質等級

抗體表格

affinity purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

hamster, mouse, rat, monkey, human

製造商/商標名

Chemicon®

技術

western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

phosphorylation (pSer368)

基因資訊

human ... GJA1(2697)

特異性

Recognizes Ser368 phosphorylated Connexin 43. Connexin 43 (Cx43) is a member of the large family of gap junction proteins. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap-junction communication is important in development and regulation of cell growth.

免疫原

Epitope: phospho-specific (Ser368)
KLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Ser368 of human Connexin 43.

應用

Research Category
Cell Structure
Research Sub Category
Adhesion (CAMs)
This Anti-Connexin 43 Antibody, phospho-specific (Ser368) is validated for use in WB for the detection of Connexin 43.
Western blotting 1:1,000 (for best results, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight)

Optimal working dilutions must be determined by the end user.

外觀

Protein A and peptide affinity purified immunoglobulin. Liquid in 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, with 50% glycerol.

儲存和穩定性

Maintain at -20ºC for 12 months after date of receipt. Do not aliquot.

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2


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Mechanisms of unpinning and termination of ventricular tachycardia.
Ripplinger, CM; Krinsky, VI; Nikolski, VP; Efimov, IR
American Journal of Physiology. Heart and Circulatory Physiology null
Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43.
Azarashvili, T; Baburina, Y; Grachev, D; Krestinina, O; Evtodienko, Y; Stricker, R; Reiser, G
American Journal of Physiology. Cell Physiology null
David Johansen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 28(1), 103-114 (2011-08-26)
Gap junction intercellular communication (GJIC) and hemichannel permeability may have important roles during an ischemic insult. Our aim was to evaluate the effect of ischemia on gap junction channels and hemichannels. We used neonatal rat heart myofibroblasts and simulated ischemia
Ronald Ng et al.
JCI insight, 5 (2019-06-14)
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder with variable genetic etiologies. Here we focused on understanding the precise molecular pathology of a single clinical variant in DSP, the gene encoding desmoplakin. We initially identified a novel missense desmoplakin variant (p.R451G)
Florian Alonso et al.
Cardiovascular research, 87(1), 166-176 (2010-01-30)
Connexins (Cxs) play a role in the contractility of the aorta wall. We investigated how connexins of the endothelial cells (ECs; Cx37, Cx40) and smooth muscle cells (SMCs; Cx43, Cx45) of the aorta change during renin-dependent and -independent hypertension. We

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