AB2277

Anti-FOXP1 Antibody

from rabbit, purified by affinity chromatography

• 别名: fork head-related protein like B, forkhead box P1, glutamine-rich factor 1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: rhesus macaque, rat, mouse, human
• 物種活性（以同源性預測）: bovine (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology)
• 技術: immunocytochemistry: suitable; immunohistochemistry: suitable; western blot: suitable
• NCBI登錄號: NP_116071
• UniProt登錄號: Q9H334
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FOXP1(27086)

说明

一般說明

Forkhead box protein 1 (FOXP1) is a member of the Forkhead family of transcription factors, which have been characterized as transcriptional repressors and activators, and as having a DNA-binding domain distinguished by its formation of a winged-helix motif. FOXP1 is known to be an important regulator of airway morphogenesis, lung epithelial development, and early cardiac development. It is also known to have an important role in conjunction with NFκβ in the development of B-cells and the differentiation of macrophages. Splice variants give rise to four isoforms of FOXP1. The protein is known to form homodimers and heterodimers with FOXP2 and FOXP4. Studies have indicated FOXP1 as a potential inducer of oncogenesis when over expressed. The depletion and mutation of FOXP1 expression may lead to defects in embryonic cardiac, lung and esophagus epithelial development.

特異性

This antibody recognizes the C-terminus of FOXP1.

免疫原

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human FOXP1.

應用

Anti-FOXP1 Antibody detects level of FOXP1 & has been published & validated for use in WB, IC, IH.

Immunohistochemistry Analysis: A 1:300 dilution of AB2277 from a previous lot detected FOXP1 in inflammatory skin disorder and normal human kidney-glomerulus tissue.

Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected FOXP1 in NIH/3T3, RAW264.7, and HeLa cells.

Research Category
Neuroscience

Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Transcription Factors

品質

Evaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected multiple isoforms of FOXP1 in 10 µg of Jurkat cell lysate.

標靶描述

FOXP1 has 4 isoforms observed at 75/73, 64 and 54 kDa

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

分析報告

Control
Jurkat cell lysate

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable