跳转至内容
Merck
所有图片(2)

主要文件

AB2261

Sigma-Aldrich

抗Tbr1抗体

from chicken, purified by affinity chromatography

别名:

T-box, brain, 1

登录查看公司和协议定价


About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

chicken

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

human, mouse, rat

物種活性(以同源性預測)

opossum (based on 100% sequence homology), horse (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology), pig (based on 100% sequence homology)

技術

immunohistochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

mouse ... Tbr1(21375)

一般說明

Tbr1基因是一个保守的基因家族的成员,该家族共享一个共同的DNA结合结构域T-box。T-box基因编码参与发育过程调控的转录因子。Tbr1是一种已知在有丝分裂后神经元中表达的推定转录因子,已在谷氨酸能的早产皮质神经元中高度表达。类似的蛋白已在小鼠中被破坏,并显示出对早期皮质发育至关重要,并导致嗅球和嗅觉皮质中投射神经元的丢失。发现Tbr1衍生的蛋白的C末端区域对于与钙/钙调蛋白依赖性丝氨酸蛋白激酶的鸟苷酸激酶结构域关联性是必要和充分的。

特異性

该抗体可识别Tbr1。

免疫原

对应于小鼠Tbr1的KLH偶联线性肽。
表位:内部

應用

免疫组化分析: 一个先前批次的1:100稀释液在小鼠额叶皮质组织中检测到Tbr1。
抗Tbr1抗体是用于WB,IH的针对Tbr1的抗体。
研究子类别
发育神经科学
研究类别
神经科学

品質

通过蛋白质印迹在人胎脑组织裂解液中进行了评估。

蛋白质印迹分析:0.025 µg/mL的该抗体在10 µg人胎脑组织裂解液中检测到Tbr1。

標靶描述

观察值为~ 68 kDa;然而,UniProtKB/Swiss-Prot条目Q64336(TBR1_MOUSE)列出了73.941 kDa的质量

外觀

亲和纯化
纯化的鸡多克隆抗体溶于含0.1 M Tris-甘氨酸(pH 7.4,150 mM NaCl)和0.05%叠氮化钠的缓冲液中。

儲存和穩定性

自发运之日起,在 2-8°C 条件下可稳定保存1年

分析報告

对照
人胎脑组织裂解液

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

未找到合适的产品?  

试试我们的产品选型工具.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Tadashi Nomura et al.
Cell reports, 31(5), 107592-107592 (2020-05-07)
The six-layered neocortex is a shared characteristic of all mammals, but not of non-mammalian species, and its formation requires an inside-out pattern of neuronal migration. The extant reptilian dorsal cortex is thought to represent an ancestral form of the neocortex
Anna Gorelik et al.
Nature communications, 8, 15096-15096 (2017-05-04)
In recent years the notion that malfunctioning of the immune system may result in developmental brain diseases has emerged. However, the role of immune molecules in the developing brain has not been well explored. The complement pathway converges to cleave
Livio Oboti et al.
eNeuro, 5(3) (2018-06-19)
Interconnections between the olfactory bulb and the amygdala are a major pathway for triggering strong behavioral responses to a variety of odorants. However, while this broad mapping has been established, the patterns of amygdala feedback connectivity and the influence on
Naoki Nakagawa et al.
Genes & development, 31(16), 1679-1692 (2017-09-17)
Adenomatous polyposis coli (APC) regulates the activity of β-catenin, an integral component of Wnt signaling. However, the selective role of the APC-β-catenin pathway in cerebral cortical development is unknown. Here we genetically dissected the relative contributions of APC-regulated β-catenin signaling
Lei Wang et al.
Nature neuroscience, 19(7), 888-896 (2016-05-24)
The unique mental abilities of humans are rooted in the immensely expanded and folded neocortex, which reflects the expansion of neural progenitors, especially basal progenitors including basal radial glia (bRGs) and intermediate progenitor cells (IPCs). We found that constitutively active

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门