AB2083
Anti-CD44v7 Antibody, exon v7
Chemicon®, from rabbit
别名:
Anti-CDW44, Anti-CSPG8, Anti-ECMR-III, Anti-HCELL, Anti-HUTCH-I, Anti-IN, Anti-LHR, Anti-MC56, Anti-MDU2, Anti-MDU3, Anti-MIC4, Anti-Pgp1
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所有图片(1)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
無性繁殖:
polyclonal
application:
ELISA
FACS
ICC
IHC
IP
WB
FACS
ICC
IHC
IP
WB
物種活性:
mouse, human, bovine, rabbit, rat, canine, pig
技術:
ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
citations:
1
推荐产品
生物源
rabbit
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
mouse, human, bovine, rabbit, rat, canine, pig
製造商／商標名
Chemicon®
技術
ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
unmodified
基因資訊
human ... CD44(960)
特異性
CD44v7 (Approximant 200-250 kDa)
Recent studies indicate that the expression of CD44 on the cell surface changes profoundly during tumor metastasis, particularly during the progression of various carcinomas. Sequencing analysis reveals that CD44 exists in different forms (at least 15 isoforms have been identified) that are variants of the common or standard hemopoietic form CD44s. Specifically, the human CD44 gene contains 19 exons, out of which 10 exons can potentially be alternatively spliced. In particular, CD44s contains exons 1-15 and exons 15-19. The other exons (e.g. 6-14) are also spliced in a variety of different cells. For example, epithelial cells contain exons 12-14 inserted into the CD44s transcripts. This isoform has been designated as CD44E. Other CD44 variants CD44v) have the same sequences at the two ends of the molecule, but differ in a middle region (with different numbers of additional exons) located on the external side of the cell membrane. It has been suggested that expression of CD44 variants with the additional exon 11 (so-called v7) is responsible for tumor progression and metastasis. In fact, CD44v7 expression has been used as an indicator of metastasis
Recent studies indicate that the expression of CD44 on the cell surface changes profoundly during tumor metastasis, particularly during the progression of various carcinomas. Sequencing analysis reveals that CD44 exists in different forms (at least 15 isoforms have been identified) that are variants of the common or standard hemopoietic form CD44s. Specifically, the human CD44 gene contains 19 exons, out of which 10 exons can potentially be alternatively spliced. In particular, CD44s contains exons 1-15 and exons 15-19. The other exons (e.g. 6-14) are also spliced in a variety of different cells. For example, epithelial cells contain exons 12-14 inserted into the CD44s transcripts. This isoform has been designated as CD44E. Other CD44 variants CD44v) have the same sequences at the two ends of the molecule, but differ in a middle region (with different numbers of additional exons) located on the external side of the cell membrane. It has been suggested that expression of CD44 variants with the additional exon 11 (so-called v7) is responsible for tumor progression and metastasis. In fact, CD44v7 expression has been used as an indicator of metastasis
免疫原
Epitope: exon v7
Synthetic peptide of human CD44v7
應用
Detect CD44v7 using this Anti-CD44v7 Antibody, exon v7 validated for use in ELISA, FC, IP, WB, IC, IH(P).
ELISA: 1:1,000-1:2,000
Flow Cytometry: 1:500-1:1,000
Immunofluorescence: 1:100-1:200
Immunohistostaining of paraffin embedded tissue: 1:150-1:250
Immunoprecipitation: 1:100-1:200
Western Blotting: 1:5,000-1:10,000
Optimal working dilutions must be determined by the end user.
Flow Cytometry: 1:500-1:1,000
Immunofluorescence: 1:100-1:200
Immunohistostaining of paraffin embedded tissue: 1:150-1:250
Immunoprecipitation: 1:100-1:200
Western Blotting: 1:5,000-1:10,000
Optimal working dilutions must be determined by the end user.
聯結
Replaces: 04-1123
外觀
Format: Purified
Purified immunoglobulin. Liquid in 10 mM sodium phosphate, pH 7.5 with 150 mM NaCl with 0.01% sodium azide.
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
CD44 differentially activates mouse NK T cells and conventional T cells.
Jonathan Larkin, Gourapura J Renukaradhya, Venkataraman Sriram, Wenjun Du et al.
Journal of immunology (Baltimore, Md. : 1950) (1950)
Surface protein expression and messenger RNA-splicing analysis of CD44 in uterine cervical cancer and normal cervical epithelium.
Dall, P; Heider, KH; Hekele, A; von Minckwitz, G; Kaufmann, M; Ponta, H; Herrlich, P
Cancer Research null
R Arch et al.
Science (New York, N.Y.), 257(5070), 682-685 (1992-07-31)
A variant of the glycoprotein CD44 (CD44v) that shares sequences with variants causally involved in metastasis formation is transiently expressed on B and T lymphocytes and macrophages after antigenic stimulation and in the postnatal period. Antibodies to the variant hinder
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