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Key Documents

AB15794

Sigma-Aldrich

抗-Dexras1抗体

Chemicon®, from rabbit

别名:

Activator of G-Protein Signaling 1, AGS1

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

mouse

物種活性(以同源性預測)

rat (100% immunogen homology), human (100% immunogen homology)

製造商/商標名

Chemicon®

技術

western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... RASD1(51655)

一般說明

Dexras1是Ras-G-蛋白超家族的成员,直接与Gialpha异源三聚体G蛋白结合,它似乎促进Gialpha上的鸟嘌呤核苷酸交换。Dexras1通过一氧化氮合酶参与NMDA受体信号传导。

特異性

Dexras1(G蛋白信号传导激活剂1,AGS1)。抗体通过蛋白质印迹识别小鼠脑提取物的~33 kDa的条带。该抗体还被用于检测棕色脂肪细胞裂解液中的Dexras1。
其他物种尚未经过测试

免疫原

合成肽。

應用

研究子类别
信号神经科学
研究类别
神经科学
蛋白质印迹:1:1,000,小鼠脑提取物中。
最佳工作稀释度必须由最终用户进行确定。
该抗Dexras1抗体经过验证可用于WB中,以用于检测Dexras1。

外觀

免疫亲和纯化
溶于PBS中的液体。不含防腐剂

儲存和穩定性

自发货之日起可在-70°C保存6个月

法律資訊

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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M J Cismowski et al.
The Journal of biological chemistry, 275(31), 23421-23424 (2000-06-07)
Utilizing a functional screen in the yeast Saccharomyces cerevisiae we identified mammalian proteins that activate heterotrimeric G-protein signaling pathways in a receptor-independent fashion. One of the identified activators, termed AGS1 (for activator of G-protein signaling), is a human Ras-related G-protein
T E Graham et al.
Endocrinology, 142(6), 2631-2640 (2001-05-18)
Dexras1 is a novel GTP-binding protein that shares structural similarity with the Ras family of small molecular weight GTPases and is strongly and rapidly induced during treatment with dexamethasone. The function of Dexras1 and its contribution to glucocorticoid-dependent signaling in
M J Cismowski et al.
Nature biotechnology, 17(9), 878-883 (1999-09-03)
We describe genetic screens in Saccharomyces cerevisiae designed to identify mammalian nonreceptor modulators of G-protein signaling pathways. Strains lacking a pheromone-responsive G-protein coupled receptor and expressing a mammalian-yeast Galpha hybrid protein were made conditional for growth upon either pheromone pathway
Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart.
McGrath, MF; Ogawa, T; de Bold, AJ
American Journal of Physiology. Heart and Circulatory Physiology null
M Fang et al.
Neuron, 28(1), 183-193 (2000-11-22)
Because nitric oxide (NO) is a highly reactive signaling molecule, chemical inactivation by reaction with oxygen, superoxide, and glutathione competes with specific interactions with target proteins. NO signaling may be enhanced by adaptor proteins that couple neuronal NO synthase (nNOS)

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