推荐产品
生物源
rabbit
品質等級
抗體表格
serum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
mouse, human, rat
製造商／商標名
Chemicon®
技術
immunoprecipitation (IP): suitable
western blot: suitable
適合性
not suitable for immunohistochemistry
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
目標翻譯後修改
unmodified
基因資訊
human ... GRIN2B(2904)
特異性
Recognizes NMDAR2B. By Western blot it recognizes a 180 kDa band in rat brain membranes. Also recognizes a 70 kDa band (thought to be a contaminant). No reactivity to NMDAR2A or NMDAR2C by Western blot. Immunolabeling is blocked by preadsorption of AB1557 with the C-terminal fusion protein that was used to generate the antibody.
免疫原
C-Terminal Fusion Protein of the NMDAR2B (Amino acids 984-1104).
應用
Anti-NMDAR2B Antibody, pain detects level of NMDAR2B & has been published & validated for use in IP & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
Western blotting 1:200-1:1,000 (NMDAR2B is present in high concentrations in the hippocampus)
Immunoprecipitation using solubilized hippocampal slices. 3 μL will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2B in 200 μg of rat brain lysate.
Not suggested for use in immunohistochemistry.
Note: Above dilutions are with 35S-protein A; with ECL dilutions may need to be considerably higher to obtain specific immunolabeling.
Optimal working dilutions must be determined by the end user.
Immunoprecipitation using solubilized hippocampal slices. 3 μL will (under appropriate conditions) quantitatively immunoprecipitate all NMDAR2B in 200 μg of rat brain lysate.
Not suggested for use in immunohistochemistry.
Note: Above dilutions are with 35S-protein A; with ECL dilutions may need to be considerably higher to obtain specific immunolabeling.
Optimal working dilutions must be determined by the end user.
標靶描述
180 kDa
外觀
Unpurified
Rabbit antiSerum. Liquid, no preservatives.
儲存和穩定性
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
分析報告
Control
Brain tissue, Rat Purkinje cell dendrites, rat hippocampus lysate, HEK 293 cells expressing NR2B
Brain tissue, Rat Purkinje cell dendrites, rat hippocampus lysate, HEK 293 cells expressing NR2B
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Effects of methylmercury on postnatal neurobehavioral development in mice.
Yu Gao,Yu Ding,Rong Shi,Ying Tian
Neurotoxicology and Teratology null
Kevin K Ogden et al.
PLoS genetics, 13(1), e1006536-e1006536 (2017-01-18)
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors, play key roles in normal brain development and various neurological disorders. Here we use standing variation data from the human population to assess which protein domains within NMDAR GluN1, GluN2A and GluN2B subunits
Y Honse et al.
Neuroscience, 122(3), 689-698 (2003-11-19)
N-methyl-D-aspartate receptor dysfunction has been strongly suggested to link with the abnormalities seen in fetal alcohol syndrome. Thus, the effects of prenatal ethanol exposure on the total expression of NR1 splice variants and the cell surface expression of both NR1
Elisa A Waxman et al.
The Journal of biological chemistry, 280(32), 29322-29333 (2005-06-22)
N-methyl-d-aspartate receptor (NMDAR) stimulation activates many downstream mechanisms involved in both cell survival and cell death. The manner in which the NMDAR regulates one of these pathways, the p38 mitogen-activated protein kinase (p38) pathway, is currently unknown. In the present
Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology.
Joie A Bernard-Trifilo, Eniko A Kramar, Reidun Torp, Ching-Yi Lin, Eduardo A Pineda et al.
Journal of Neurochemistry null
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