AB15080

Anti-Frataxin Antibody

from rabbit

• 别名: Anti-CyaY, Anti-FA, Anti-FARR, Anti-FRDA, Anti-X25
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 物種活性: rat, mouse, human
• 技術: western blot: suitable
• NCBI登錄號: NP_000135
• UniProt登錄號: Q16595
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... FXN(2395) ; mouse ... Fxn(14297) ; rat ... Fxn(499335)

说明

一般說明

Frataxin is a nuclear encoded protein that is found in the mitochondria. This protein is not well understood but may be involved with iron sulfur clusters. In humans the gene is localized on chromosome 9 and is highly conserved during evolution. The gene is expressed in every cell, although in varying levels in different tissues and during development. The specific function of Frataxin is still unknown, but it has been shown to play a role in iron metabolism. Studies have demonstrated that the deletion of the Frataxin gene in yeast results in iron accumulation in mitochondria and loss of respiration. Recombinant human Frataxin has been shown to bind iron in vitro, and increased mitochondrial iron levels have been observed in patients with Friedreich′s Ataxia (FRDA).

特異性

Cat. # AB15080 recognizes Frataxin.

免疫原

Epitope: mature chain

GST-tagged Frataxin corresponding to mature chain.

應用

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

This Anti-Frataxin Antibody is validated for use in WB for the detection of Frataxin.

品質

Routinely evaluated by Western Blot on Human heart lysates.

Western Blot Analysis: 1:1,000 - 1:10,000 dilution of this lot detected Frataxin on 10 ug of human heart lysate

標靶描述

Approx. 18 kDa

外觀

GST-depleted sera

Format: Purified

Rabbit polyclonal serum in buffer containing 0.05% NaN3.

儲存和穩定性

Stable for 1 year at -20ºC from date of receipt.

分析報告

Control
Human heart lysate.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable