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Merck
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Key Documents

8.53008

Sigma-Aldrich

Boc-His(Dnp)-OH isopropanol

Novabiochem®

别名:

Boc-His(Dnp)-OH isopropanol, N-α-t.-Boc-N-im-dinitrophenyl-L-histidine isopropanol

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About This Item

经验公式(希尔记法):
C17H19N5O8 · xC3H8O
分子量:
421.36
分類程式碼代碼:
12352209
NACRES:
NA.22

品質等級

產品線

Novabiochem®

化驗

≥98% (TLC)

形狀

powder

反應適用性

reaction type: Boc solid-phase peptide synthesis

製造商/商標名

Novabiochem®

應用

peptide synthesis

儲存溫度

15-25°C

一般說明

Standard building block for introduction of histidine amino-acid residues by Boc SPPS. The Dnp group is stable to HF and TFMSA. Normally removed with thiophenol prior to HF treatment.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

聯結

Replaces: 04-12-0023

分析報告

Color (visual): white to yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in EtOAc): +52.5 - +59.5 °
Purity (TLC(011C)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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实验方案

The most popular reagent for cleavage of peptides from Boc-based resins is anhydrous HF. Of all the cleavage procedures HF appears to be the most versatile and least harmful to a wide variety of peptides synthesized on Boc-based resins.

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