681636-M

W-13, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

• 别名: W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
• 经验公式（希尔记法）: C₁₄H₁₇ClN₂O₂S · xHCl
• CAS号: 88519-57-7
• 分子量: 312.81 (free base basis)
• MDL號碼: MFCD00058030
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: water: 35 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
• InChI 密鑰: QKAALLVQBOLELJ-UHFFFAOYSA-N

说明

一般說明

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM) and myosin light chain kinase (IC₅₀ = 58 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

生化／生理作用

Target IC₅₀: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase

警告

Toxicity: Standard Handling (A)

分析報告

single spot by TLC

其他說明

Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable