676950-M

Veratridine

≥98% (TLC), solid, Na⁺ channel opener, Calbiochem

• 别名: Veratridine
• 经验公式（希尔记法）: C₃₆H₅₁NO₁₁
• CAS号: 71-62-5
• 分子量: 673.79
• MDL號碼: MFCD00082515
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 产品名称: Veratridine, A Na⁺ channel opener.
• 品質等級: 100
• 描述: Merck USA index - 14, 9954
• 化驗: ≥98% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white to yellow
• 溶解度: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: N21[C@H]([C@]([C@@]3([C@H]([C@]4([C@]([C@H]5[C@]6(O[C@]7([C@H]([C@@]6(CC[C@@H]7OC(=O)c8cc(c(cc8)OC)OC)C)CC5)O)C4)(C[C@@H]3O)O)O)C2)O)(O)C)CC[C@@H](C1)C
• InChI: 1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
• InChI 密鑰: FVECELJHCSPHKY-YFUMOZOISA-N

说明

一般說明

A Na⁺ channel opener. Increases intracellular Ca²⁺ levels without affecting Na⁺ - Ca²⁺ exchange. Acts at neurotoxin receptor site 2 and preferentially binds to activated Na⁺ channels causing persistent activation. Induces cell death in bovine chromaffin cells.

生化／生理作用

Primary Target
Na+ channel

警告

Toxicity: Highly Toxic (H)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Maroto, R., et al. 1994. Eur. J. Pharmacol. 270, 331.
Plattner, H., et al. 1994. J. Membr. Biol. 142, 229.
Rando, T.A., et al. 1989. J. Gen. Physiol.93, 43.
Rando, T.A., et al. 1986. Mol. Pharmacol.29, 467.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300 + H310 + H330,H315,H319,H335
• 防範說明: P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• 危險分類: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable