推荐产品
product name
U18666A, A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol.
品質等級
化驗
≥95% (HPLC)
形狀
lyophilized solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
顏色
white
溶解度
water: 10 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H
InChI 密鑰
ICPRVJHNLABCSA-UHFFFAOYSA-N
一般說明
A cell-permeable, amphiphilic amino-steroid that alters intracelluar membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol. Reported to exert its effects via the inhibition of 2,3-oxidosqualene-lanosterol cyclase activity. Also reported to inhibit the activity of Δ8-sterol isomerase.
A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol, presumably via its inhibitory effect on 2,3-oxidosqualene-lanosterol cyclase activity. Also reported to inhibit the activity of Δ8-sterol isomerase.
生化／生理作用
Cell permeable: yes
Primary Target
Activity of δ8-sterol isomerase
Activity of δ8-sterol isomerase
Product does not compete with ATP.
Reversible: no
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Hall, A.M., et al. 2003. Pigment Cell Res.16, 149.
Kobayashi, T., et al. 1998. Nature392, 193.
Liscum, L. and Faust, J.R., 1989. J. Biol. Chem.264, 11796.
Sexton, R.C., et al. 1983. Biochemistry22, 5687.
Bierkamper, G.G. and Cenedella, R.J., 1978. Brain Res.150, 343.
Kobayashi, T., et al. 1998. Nature392, 193.
Liscum, L. and Faust, J.R., 1989. J. Biol. Chem.264, 11796.
Sexton, R.C., et al. 1983. Biochemistry22, 5687.
Bierkamper, G.G. and Cenedella, R.J., 1978. Brain Res.150, 343.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Gianluca Scerra et al.
iScience, 24(7), 102707-102707 (2021-07-15)
Lysosome functions mainly rely on their ability to either degrade substrates or release them into the extracellular space. Lysosomal storage disorders (LSDs) are commonly characterized by a chronic lysosomal accumulation of different substrates, thereby causing lysosomal dysfunctions and secretion defects.
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