616400-M

Tranilast

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.

• 别名: Tranilast, N-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
• 经验公式（希尔记法）: C₁₈H₁₇NO₅
• CAS号: 53902-12-8
• 分子量: 327.33
• MDL號碼: MFCD00864787
• 分類程式碼代碼: 51111800

属性

• 品質等級: 100
• 描述: Merck USA index - 14, 9570
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: pale yellow
• 溶解度: DMSO: 200 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: N(c2c(cccc2)C(=O)O)C(=O)\C=C\c1cc(c(cc1)OC)OC
• InChI: 1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
• InChI 密鑰: NZHGWWWHIYHZNX-CSKARUKUSA-N

说明

一般說明

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca²⁺ mobilization in vascular smooth muscle.

生化／生理作用

Primary Target
VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°C).

其他說明

Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
Isaji, M., et al. 1998. Life Sci. 63, PL71.
Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable