572632-M

SU5614

A potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC₅₀ = 1.2 µM) and PDGF (IC₅₀ = 2.9 µM) receptor tyrosine kinases.

• 别名: SU5614, 5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone, VEGFR Tyrosine Kinase Inhibitor VII, VEGFR2 Kinase Inhibitor IX
• 经验公式（希尔记法）: C₁₅H₁₃ClN₂O
• CAS号: 186611-56-3
• 分子量: 272.73
• 分類程式碼代碼: 12352200

属性

• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: orange-red
• 溶解度: DMSO: 10 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19)
• InChI 密鑰: XLBQNZICMYZIQT-UHFFFAOYSA-N

说明

一般說明

A potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC₅₀ = 1.2 µM) and PDGF (IC50 = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC₅₀ ≤680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.

A potent, cell-permeable, reversible, ATP-competitive, and selective inhibitor of VEGF (Flk-1; IC₅₀ = 1.2 µM) and PDGF (IC₅₀ = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC₅₀ ≤ 680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells.

生化／生理作用

Primary Target
VEGF Flk-1

Target IC₅₀: 1.2 µM, 2.9 µM against VEGF (Flk-1) and PDGF receptor tyrosine kinases, respectively; ≤680 nM against the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs)

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他說明

Cools, J., et al. 2004. Cancer Res.64, 6385.
Sun, L., et al. 1998. J. Med. Chem. 41, 2588.

法律資訊

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable