推荐产品
产品名称
Rac1抑制剂, Rac1 Inhibitor, CAS 1177865-17-6, is a cell-permeable, reversible inhibitor of Rac1 GDP/GTP exchange. Interferes with the interaction between Rac1 and Rac-specific GEFs Trio and Tiam1 (IC₅₀ ~50 µM).
品質等級
化驗
≥93% (HPLC)
形狀
lyophilized
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
溶解度
water: 5 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C24H35N7.3ClH/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22;;;/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30);3*1H
InChI 密鑰
CPUHORIUXPQCHW-UHFFFAOYSA-N
一般說明
一种细胞渗透性嘧啶化合物，通过干扰Rac1和Rac特异性GEF（鸟嘌呤核苷酸交换因子）Trio和Tiam1（IC50 ~50 µM）之间的相互作用，特异性和可逆地抑制Rac1 GDP/GTP交换活性。显示有效抑制NIH3T3和PC-3细胞中Rac1介导的细胞功能（有效剂量~50至100 μM）。对Cdc42或RhoA激活无影响，且不影响Rac1与BcrGAP或PAK1的相互作用。减少TRAP诱导和胶原刺激的血小板聚集（IC50分别为50 mM和64 mM）。
生化／生理作用
主要靶标
Rac1
Rac1
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：针对Rac1 GDP/GTP交换活性约为50µM；针对TRAP诱导和胶原蛋白刺激的血小板聚集为50 mM和64 mM
包裝
用惰性气体包装
警告
毒性：致癌/致畸（D）
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他說明
Dwivedi, S., et al. 2010.J. Translational Med.8, 128.
Desire, L., et al. 2005.J. Biol. Chem.280, 37516.
Gao, Y., et al. 2004.Proc.Natl.Acad.Sci. USA101, 7618.
Desire, L., et al. 2005.J. Biol. Chem.280, 37516.
Gao, Y., et al. 2004.Proc.Natl.Acad.Sci. USA101, 7618.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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