551590

Quercetagetin

A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC₅₀ = 340 nM).

• 别名: Quercetagetin, 3,3ʹ,4ʹ,5,6,7-Hexahydroxyflavone
• 经验公式（希尔记法）: C₁₅H₁₀O₈
• CAS号: 90-18-6
• 分子量: 318.24
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow to yellow-green
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
• InChI 密鑰: ZVOLCUVKHLEPEV-UHFFFAOYSA-N

说明

一般說明

A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC₅₀ = 340 nM). Exhibits ≥7-fold selectivity over 8 other kinases tested, including PIM2 (IC₅₀ = 3.45 µM), and little activity toward c-Abl even at concentrations as high as 200 µM. Inhibits cellular BAD phosphorylation (IC₅₀ = 5.5 µM) and induces growth arrest (ED₅₀ = 3.8 µM) in PIM1-expressing RWPE2 cells.

生化／生理作用

Cell permeable: yes

Primary Target
PIM1 kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 340 nM against PIM1 kinase

包裝

Packaged under inert gas

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Holder, S., et al. 2007. Mol. Cancer Ther.6, 163.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable