539162
Proteasome Inhibitor II
The Proteasome Inhibitor II controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Proteasome Inhibitor II, (Benzyloxycarbonyl)-Leu-Leu-phenylalaninal, Z-LLF-CHO
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About This Item
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品質等級
化驗
≥95% (HPLC)
形狀
lyophilized solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
desiccated
顏色
white
溶解度
DMSO: 5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
一般說明
A potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells.
生化/生理作用
Cell permeable: yes
Primary Target
MPC
MPC
Product does not compete with ATP.
Reversible: yes
Target Ki: 460 nM against the pituitary multicatalytic proteinase complex (MPC)
警告
Toxicity: Standard Handling (A)
序列
Z-Leu-Leu-Phe-CHO
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
其他說明
Schauer, S.L., et al. 1998. J. Immunol. 160, 4398.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.
Orlowski, M., et al. 1997. Biochemistry 36, 13946.
Orlowski, M., et al. 1993. Biochemistry 32, 1563.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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