推荐产品
品質等級
化驗
≥97% (HPLC)
形狀
solid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
DMSO: 100 mg/mL
ethanol: 20 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13-,15+/m0/s1
InChI 密鑰
KTEXNACQROZXEV-QLIGOWBFSA-N
一般說明
A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
A sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
生化/生理作用
Cell permeable: yes
Primary Target
the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
其他說明
Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
其他客户在看
Journal of immunology (Baltimore, Md. : 1950), 174(3), 1701-1708 (2005-01-22)
Chlamydia trachomatis, an obligate intracellular bacterial species, is known to inhibit host cell apoptosis. However, the chlamydial antiapoptotic mechanism is still not clear. Because NF-kappaB activation is antiapoptotic, we tested the potential role of NF-kappaB activation in chlamydial antiapoptotic activity
The British journal of dermatology, 159(1), 68-76 (2008-05-15)
Pemphigus vulgaris (PV) is a blistering autoimmune disease characterized by IgG autoantibodies against desmoglein 3. Nitric oxide synthases (NOS) may contribute to the increase of inflammation in tissues by the generation of nitrotyrosine residues (NTR). To investigate whether the production
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门