5.05823

Galectin-1 Antagonist, DB21

• 别名: Galectin-1 Antagonist, DB21, SVQNvaKL-[DBF]-IIVKLNA
• 经验公式（希尔记法）: C₈₃H₁₃₂N₁₈O₁₇
• 分子量: 1654.05
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: powder
• 效力: 3 μM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 10 mg/mL
• 儲存溫度: −20°C

说明

一般說明

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC₅₀ = 3 µM). Shown to reduce the proliferation of endothelial cells and reduce vessel density in murine tumor models.

生化／生理作用

Primary Target
Galectin-1

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

SVQMKNva-[DBF]-IIVKLNA

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Dings, R.P., et al, 2013, J. Pharm. Exp. Ther.344, 589.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable