5.05207

Mecamylamine Hydrochloride

• 别名: Mecamylamine Hydrochloride, N,2,3,3-Tetramethylbicyclo[2.2.1]he­ptan-2-amine hydrochloride, TC-5214, Inversine, nAChR Antagonist, Mecamylamine hydrochloride
• 经验公式（希尔记法）: C₁₁H₂₁N · xHCl
• CAS号: 826-39-1
• 分子量: 167.29 (free base basis)
• MDL號碼: MFCD00151462
• 分類程式碼代碼: 12352116
• NACRES: NA.77

属性

• 化驗: ≥98% (TLC)
• 品質等級: 100
• 形狀: solid
• 效力: 640 nM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: H₂O: 100 mM
• 儲存溫度: 2-8°C
• InChI: 1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
• InChI 密鑰: PKVZBNCYEICAQP-UHFFFAOYSA-N

说明

一般說明

A potent, nonselective, and noncompetitive antagonist of nAChRs (IC₅₀ = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette′s syndrome, Schizophrenia and various cognitive and mood disorders).

生化／生理作用

Primary Target
nAChR

Reversible: yes

警告

Toxicity: Toxic (F)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Harris, C., et al. 2013. Psychopharmacol.225, 291.
Lima, H., et al. 2013. Learning & Memory20, 120.
Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol.22, 198.
Bacher, I., et al. 2009. Expert Opin. Pharmacother.10, 2709.
Lippiello, M., et al. 2008. CNS Neurosci. Ther.14, 266.br>J. M. Young et al. 2001. Clin. Ther.23, 532.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable