444294-M

MMP-2 Inhibitor IV

The MMP-2 Inhibitor IV controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 别名: MMP-2 Inhibitor IV, (4′-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid, Bone Resorption Inhibitor, Bone Resorption Inhibitor, (4′-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
• 经验公式（希尔记法）: C₁₃H₁₄ClNO₈P₂S
• 分子量: 441.72
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 100 mg/mL, clear, colorless
• 儲存溫度: 2-8°C

说明

一般說明

A cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC₅₀ = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (>1 M), and MMP-14 (>1 M). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC₅₀ = 1.7 M), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC₅₀ = 30 M), and Zolendronate (7.8 M), without observable cytotoxicity in HepG2 cells. At 25 M, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Rubino, M.T., et al. 2011. Chem. Med. Chem.6, 1258.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable