407241

Insulin Degrading Enzyme, His•Tag^®, Rat, Recombinant, S. frugiperda

• 别名: Insulysin, IDE
• EC 号: 3.4.24.56 (BRENDA, IUBMB)
• 分類程式碼代碼: 12352202
• NACRES: NA.25

属性

• 化驗: ≥90% (SDS-PAGE)
• 品質等級: 100
• 形狀: liquid
• 比活性: ≥3 units/mg protein
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 運輸包裝: wet ice
• 儲存溫度: −70°C

说明

一般說明

Recombinant, rat insulin degrading enzyme fused to a His•Tag sequence and expressed in S. frugiperda insect cells. Insulin degrading enzyme (Insulysin) is a metalloprotease that degrades insulin and a variety of other peptides, including glucagon, insulin-like growth factors I and II, atrial natriuretic peptide, TGF-α, and amyloid peptides. Reported to be inversely correlated with brain Aβ peptide levels in insulysin-deficient mice compared to wild-type mice.

包裝

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

單位定義

One unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.

外觀

In 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.

重構

Following initial thaw, aliquot and freeze (-70°C).

其他說明

Hersh, L.B. 2003. Curr. Pharm. Des.9, 449.
Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA100, 6221.
Song, E.S., et al. 2003. J. Biol. Chem.278, 49789.
Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimer′s Dis.4, 341.
Song, E.S., et al. 2001. J. Biol. Chem.276, 1152.
Becker, A.B., and Roth, R.A. 1995. Methods Enzymol.248, 693.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1