219477

Cdk4 Inhibitor II, NSC 625987

The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: Cdk4 Inhibitor II, NSC 625987, 1,4-Dimethoxyacridine-9(10H)-thione
• 经验公式（希尔记法）: C₁₅H₁₃NO₂S
• CAS号: 141992-47-4
• 分子量: 271.33
• MDL號碼: MFCD08276925
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: brown
• 溶解度: ethanol: 2.5 mg/mL; DMSO: 25 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C15H13NO2S/c1-17-11-7-8-12(18-2)14-13(11)15(19)9-5-3-4-6-10(9)16-14/h3-8H,1-2H3,(H,16,19)
• InChI 密鑰: KFAKESMKRPNZTM-UHFFFAOYSA-N

说明

一般說明

A potent, reversible, and substrate-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC₅₀ >100 µM).

A thioacridone compound that acts as a reversible and potent substrate-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 200 nM). Displays ~500-fold greater selectivity for Cdk4/cyclin D1 over Cdc2/cyclin A (Cdk1/cyclin A), Cdk2/cyclin A, and Cdk2/cyclin E (IC₅₀ >100 µM).

生化／生理作用

Cell permeable: no

Primary Target
CDK4/D1

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 200 nM against CDK4/D1

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Kubo, A., et al. 1999. Clin. Cancer Res.5, 4279.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3