124038

InSolution Akt 抑制剂 V，曲西立滨-CAS 35943-35-2-Calbiochem

InSolution, ≥95%

• 别名: InSolution Akt Inhibitor V, Triciribine
• 经验公式（希尔记法）: C₁₃H₁₆N₆O₄
• CAS号: 35943-35-2
• 分子量: 320.30
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 運輸包裝: ambient
• 儲存溫度: −70°C
• InChI: 1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
• InChI 密鑰: HOGVTUZUJGHKPL-HTVVRFAVSA-N

说明

一般說明

A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.

重構

Following intitial thaw, aliquot and freeze (-70°C).

其他說明

Karst, A., et al. 2006. Cancer Res.66, 9225.
Yang, L., et al. 2004. Cancer Res.64, 4394.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 188.6 °F - closed cup - (Dimethylsulfoxide)
• 閃點（°C）: 87 °C - closed cup - (Dimethylsulfoxide)