119120

腺苷5′-O-(3-硫代三磷酸)，四锂盐

A relatively stable, slowly hydrolyzable ATP analog that can substitute for ATP in various kinase reactions. Used as a substrate and as an inhibitor of ATP-dependent enzyme systems.

• 别名: 腺苷5′-O-(3-硫代三磷酸)，四锂盐, ATP-γ-S, 4Li
• 经验公式（希尔记法）: C₁₀H₁₂N₅O₁₂P₃S · 4Li
• CAS号: 93839-89-5
• 分子量: 546.98
• MDL號碼: MFCD00077293
• 分類程式碼代碼: 12352208
• NACRES: NA.51

属性

• 品質等級: 100
• 化驗: ≥85% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 雜質: <10% ADP
• 顏色: white
• 溶解度: water: 10 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• InChI: 1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
• InChI 密鑰: DWQFDOIBOYDYKH-KWIZKVQNSA-J

说明

一般說明

一种相对稳定、缓慢水解的ATP类似物，可在各种激酶反应中替代ATP。增加Ca²⁺激活的K⁺通道的活性。用作ATP依赖性酶系统的底物和抑制剂。

一种相对稳定、缓慢水解的ATP类似物，可在各种激酶反应中替代ATP。增加Ca²⁺激活的K⁺通道的活性。用作ATP依赖性酶系统的抑制剂。

應用

• Involvement of purinergic receptors and NOD-like receptor-family protein 3-inflammasome pathway in the adenosine triphosphate-induced cytokine release from macrophages.: This study explores the role of purinergic receptors and the NOD-like receptor-family protein 3 (NLRP3) inflammasome pathway in cytokine release induced by adenosine triphosphate (ATP) in macrophages. The findings suggest potential therapeutic targets for inflammatory diseases (Gicquel et al., 2014).


• Extracellular ATP facilitates flow-induced vasodilatation in rat small mesenteric arteries.: The study demonstrates that extracellular ATP enhances flow-induced vasodilation in small mesenteric arteries in rats, indicating a significant role of ATP in vascular function and potential implications for cardiovascular therapies (Liu et al., 2004).

警告

毒性：标准处理（A）

重構

在复溶后分装并冻存（-20°C）。储备水溶液在-20°C下可稳定保存3个月。

其他說明

Troadec, J.D., et al. 1999.Pflugers Arch.437, 745.
Chung, S., et al. 1991.Science253, 560.
Litosch, I., and Fain, J.N.1986.Life Sci. 39, 187.
Chrysogelos, S., et al. 1983.J. Biol. Chem.258, 12624.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable