119114

Luciferase Inhibitor II

The Luciferase Inhibitor II, also referenced under CAS 10205-56-8, controls the biological activity of Luciferase.

• 别名: Luciferase Inhibitor II, 4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
• 经验公式（希尔记法）: C₁₅H₁₄N₂S
• CAS号: 10205-56-8
• 分子量: 254.35
• 分類程式碼代碼: 12352200
• NACRES: NA.28

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: pale green
• 溶解度: DMSO: 0.5 mg/mL; ethanol: 3 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C15H14N2S/c1-17(2)12-9-7-11(8-10-12)15-16-13-5-3-4-6-14(13)18-15/h3-10H,1-2H3
• InChI 密鑰: HYKGLCSXVAAXNC-UHFFFAOYSA-N

说明

一般說明

A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC₅₀ = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC₅₀ = 10 µM against Promega′s Kinase-Glo; ineffective against Kinase-Glo Plus and Kinase-Glo Max; at a 3-fold formulation dilution and 6.77 µM ATP).

A 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC₅₀ = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC₅₀ = 10 µM against Promega′s Kinase-Glo; ineffective against Kinase-Glo Plus and Kinase-Glo Max; at a 3-fold formulation dilution and 6.77 µM ATP).

包裝

Packaged under inert gas

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Auld, D.S., et al. 2009. J. Med. Chem.52, 1450.
Auld, D.S., et al. 2008. J. Med. Chem.51, 2372.

法律資訊

Marketed by Promega Corp. under the registered trademarks.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable