推荐产品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
2121, monoclonal
物種活性
human
包裝
antibody small pack of 25 μL
製造商／商標名
Upstate®
技術
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
基因資訊
human ... SREBF1(6720)
特異性
可与SREBP的碱性螺旋-环-螺旋亮氨酸拉链（bHLH-ZIP）发生反应。
免疫原
包含氨基酸301-407的重组His标签人SREBP-1a蛋白。
應用
抗SREBP1抗体，克隆2121，是一种小鼠单克隆抗体，可用于检测SREBP1（也被称为固醇调节元件结合转录因子1 &），其已在WB中进行验证。
品質
已通过免疫印迹进行常规评估。
標靶描述
126kda
外觀
100 μL（1 mg/mL）蛋白A纯化的小鼠单克隆IgG1，溶于含0.1％叠氮化钠的PBS中。
形式：纯化
儲存和穩定性
自收到之日起在-20°C可稳定保存2年。 第一次融化后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。 分装到微量离心管中，并储存于 -20°C。 避免反复冻融循环，以免损坏 IgG 和影响产品性能。 注意： 冷藏室温度变化至低于-20°C时可能导致-含甘油的溶液在储存过程中冻结。
其他說明
请参考特定批次的数据表。
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Tanel Punga et al.
The Journal of biological chemistry, 281(35), 25278-25286 (2006-07-11)
Members of the sterol regulatory element-binding protein (SREBP) family of transcription factors control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation. The transcription factor SREBP1 is degraded by the ubiquitin-proteasome system following phosphorylation of Thr426 and Ser430
X Wang et al.
The Journal of biological chemistry, 268(19), 14497-14504 (1993-07-05)
This paper describes the purification and characterization of a sterol regulatory element binding protein (SREBP) that recognizes the SRE-1 sequence in the 5' flanking region of the gene for the low density lipoprotein (LDL) receptor. The protein was purified more
Amy K Walker et al.
Genes & development, 24(13), 1403-1417 (2010-07-03)
The sterol regulatory element-binding protein (SREBP) transcription factor family is a critical regulator of lipid and sterol homeostasis in eukaryotes. In mammals, SREBPs are highly active in the fed state to promote the expression of lipogenic and cholesterogenic genes and
Yuichi Wakana et al.
The Journal of cell biology, 220(1) (2020-11-07)
In response to cholesterol deprivation, SCAP escorts SREBP transcription factors from the endoplasmic reticulum to the Golgi complex for their proteolytic activation, leading to gene expression for cholesterol synthesis and uptake. Here, we show that in cholesterol-fed cells, ER-localized SCAP
Farina Sultan et al.
PLoS biology, 20(5), e3001634-e3001634 (2022-05-19)
Therapeutic methods to modulate skin pigmentation has important implications for skin cancer prevention and for treating cutaneous hyperpigmentary conditions. Towards defining new potential targets, we followed temporal dynamics of melanogenesis using a cell-autonomous pigmentation model. Our study elucidates 3 dominant
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