推荐产品
等級
certified reference material
品質等級
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
濃度
1.0 mg/mL in methanol (as free base)
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
forensics and toxicology
形式
single component solution
儲存溫度
−20°C
SMILES 字串
Cl.OC(=O)C(C1CCCCN1)c2ccccc2
InChI
1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H
InChI 密鑰
SCUMDQFFZZGUQY-UHFFFAOYSA-N
一般說明
利他林酸®是哌甲酯的主要血液代谢产物，哌甲酯是一种精神兴奋药，商品名为 Concerta ®和 Ritalin®。该认证的 Snap-N-Spike ®溶液适用于尿液药物检测、临床毒理学和法医学分析的 LC/MS 或 GC/MS 应用。哌甲酯用于治疗注意力缺陷多动障碍 (ADHD)、心动过速和嗜睡症。
應用
- 非人灵长类动物的遗传毒性研究：利他林酸盐酸盐（ritalinic acid hydrochloride）是派醋甲酯的主要代谢产物，在遗传毒理学研究中用于评估潜在的遗传毒性作用，有助于评估神经药理学治疗的安全性 （Morris et al., 2009）。
- 药代动力学和致突变性研究：利他林酸盐酸盐可用于剂量范围和致突变性研究。它有助于研究哌醋甲酯的药代动力学和毒理学影响，为其在治疗应用中的安全性和有效性提供重要见解（Manjanatha et al., 2008）。
- 生物等效性和食物效应研究：在临床药理学中，利他林酸盐酸盐有助于进行右哌醋甲酯的生物等效性研究，考察了食物对药物吸收和代谢的影响，这对于药物给药方案的优化至关重要（Teo et al., 2004）。
- 儿童药物治疗：采用利他林酸盐酸盐进行的研究探讨了哌醋甲酯在进食或不进食情况下的给药效果，强调了其对药物及其酸性代谢物血浆浓度的影响，为儿科剂量指南提供了信息（Chan et al., 1983）。
- 多动症治疗研究：利他林酸盐酸盐为多动症儿童的药代动力学研究提供支持，有助于了解哌醋甲酯在体内的行为，从而改进治疗策略（Hungund et al., 1979）。
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Concerta is a registered trademark of ALZA Corporation
Ritalin is a registered trademark of Novartis Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes,Central nervous system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
其他客户在看
Mugimane G Manjanatha et al.
Environmental and molecular mutagenesis, 49(8), 585-593 (2008-07-12)
Methylphenidate hydrochloride (MPH) is one of the most frequently prescribed pediatric drugs for the treatment of attention deficit hyperactivity disorder. In a recent study, increased hepatic adenomas were observed in B6C3F1 mice treated with MPH in their diet. To evaluate
Maria del Mar Ramirez Fernandez et al.
Journal of analytical toxicology, 31(8), 497-504 (2007-11-09)
A validated method for the simultaneous analysis of multiple hallucinogens, chlorpheniramine, ketamine, ritalinic acid, and several metabolites is presented. The procedure comprises a sample clean-up step, using mixed-mode solid-phase extraction followed by liquid chromatography (LC)-tandem mass spectrometry analysis. Chromatographic separation
Emilia Marchei et al.
Clinical chemistry, 56(4), 585-592 (2010-02-20)
We studied the excretion profile of methylphenidate (MPH) and its metabolite ritalinic acid (RA) in oral fluid and plasma, the oral fluid-to-plasma (OF/P) drug ratio, and the variations of oral fluid pH after drug administration. We analyzed oral fluid and
Nicolas Barbarin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 783(1), 73-83 (2002-11-27)
This work presents a high-throughput selected reaction monitoring (SRM) LC-MS method for the determination of methylphenidate (MPH), a central nervous stimulant, and its de-esterified metabolite, ritalinic acid (RA) in rat plasma samples. A separation of these two compounds was achieved
Aygul Balcioglu et al.
Neuropharmacology, 57(7-8), 687-693 (2009-07-28)
Methylphenidate is a frequently prescribed stimulant for the treatment of attention deficit hyperactivity disorder (ADHD). An important assumption in the animal models that have been employed to study methylphenidate's effects on the brain and behavior is that bioavailability of methylphenidate
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