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C-118

Supelco

盐酸氯米帕明标准液 盐酸盐 溶液

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式（希尔记法）:
C19H24Cl2N2
CAS号:
17321-77-6
分子量:
351.31
EC號碼:
200-659-6
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

certified reference material

品質等級

300

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

濃度

1.0 mg/mL in methanol (as free base)

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing

形式

single component solution

儲存溫度

−20°C

SMILES 字串

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI 密鑰

WIMWMKZEIBHDTH-UHFFFAOYSA-N

基因資訊

human ... SLC6A4(6532)

相关类别

一般說明

Clomipramine is a tricyclic antidepressant used to many conditions from major depression and panic disorder to narcolepsy and obsessive compulsion disorder (OCD). This certified solution standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.

應用

  • Clomipramine hydrochloride solution for in vitro depression models: Research has utilized Clomipramine hydrochloride solution to develop and validate in vitro models of depression, highlighting its role as a serotonin uptake inhibitor. This aids in the pharmacokinetic profiling of antidepressants and enhances understanding of their mechanisms (Menshutina et al., 2022).
  • Application in neurotransmitter research: Clomipramine hydrochloride solution has been investigated as a tricyclic antidepressant in studies of neurotransmitter systems, particularly for its high purity and effectiveness in serotonin reuptake inhibition, essential for neurotransmitter research (Teixeira Tarley et al., 2022).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes,Central nervous system

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

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分析证书(COA)

Lot/Batch Number

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Xiaoyan Wang et al.
Journal of proteome research, 11(12), 6223-6230 (2012-11-01)
The protective effects of St John's Wort extract (SJ), ginsenosides (GS), and clomipramine (CPM) on chronic unpredictable mild stress (CUMS)-induced depression in rats were investigated by using a combination of behavioral assessments and metabonomics. Metabonomic analyses were performed using gas
Saied Saeed Hosseiny Davarani et al.
Analytica chimica acta, 725, 51-56 (2012-04-17)
Recent advances in electromembrane extraction (EME) methodology calls for effective and accessible detection methods. Using imipramine and clomipramine as model therapeutics, this proof-of-principle work combines EME with gas chromatography analysis employing a flame ionization detector (FID). The drugs were extracted
S A Savelyev et al.
Neuroscience, 212, 149-158 (2012-04-21)
Neonatal treatment of rat pups with clomipramine (CLI) has been shown to cause long-lasting and persistent depression-related behaviors and changes in sleep architecture and in brain-derived neurotrophic factor (BDNF) signaling in adult animals, producing an animal model of depression. However
M Komorowski et al.
Neuroscience, 223, 152-162 (2012-08-09)
Despair-related withdrawal behaviors are common symptoms of major depression (MD) and can be ascribed to a loss or absence of former rewarding events. Extinction of negatively reinforced escape behavior in the Morris Water Maze has been shown to induce despair-like
Nicola Luigi Bragazzi et al.
Critical reviews in eukaryotic gene expression, 22(3), 197-203 (2012-11-13)
Langmuir-Blodgett (LB) technology was used to build a high-sensitivity enzyme-based biosensor for medical purposes. Recombinant fungal laccase from Rigidoporous lignosus, as previously described, was used to catalyze a widely used antidepressant in a micromolar range, namely, clomipramine. The topological properties
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HPLC Analysis of Tricyclic Antidepressants on Ascentis® Express 2.7 μm RP-Amide

-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder; Norclomipramine hydrochloride, ~99% (TLC), powder; Imipramine hydrochloride solution, drug standard, 1.0 mg/mL in methanol; Amitriptyline hydrochloride, ≥98% (TLC), powder; Clomipramine hydrochloride, ≥98% (HPLC), powder

HPLC Analysis of Tricyclic Antidepressants on Ascentis® Express 2.7 μm RP-Amide

-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder; Norclomipramine hydrochloride, ~99% (TLC), powder; Imipramine hydrochloride solution, drug standard, 1.0 mg/mL in methanol; Amitriptyline hydrochloride, ≥98% (TLC), powder; Clomipramine hydrochloride, ≥98% (HPLC), powder

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