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Merck

A-083

Supelco

Amiodarone-D4 hydrochloride solution

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

经验公式(希尔记法):
C25D4H26ClI2NO3
分子量:
685.80
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material

形狀

liquid

特點

SNAP-N-SPIKE®, SNAP-N-SHOOT®

包裝

ampule of 1 mL

製造商/商標名

Cerilliant®

濃度

100 μg/mL in methanol (as free base)

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing

格式

single component solution

儲存溫度

−20°C

SMILES 字串

Cl.[2H]C([2H])(Oc1c(I)cc(cc1I)C(=O)c2c(CCCC)oc3ccccc23)C([2H])([2H])N(CC)CC

InChI

1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H/i13D2,14D2;

InChI 密鑰

ITPDYQOUSLNIHG-MMJSDMDPSA-N

一般說明

A Certified Spiking Solution®and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone®, Cordarone®, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.

應用


  • UV-Triggered Drug Release from Nanoparticles: Research explores the enhanced antibacterial activity of berberine hydrochloride-loaded mesoporous titanium nanoparticles, activated by UV exposure, providing insights into novel drug delivery systems for antiarrhythmic drugs like Amiodarone-D₄ hydrochloride in medical treatments (Zuo et al., 2024).

  • Antioxidant Activity and Eczema Treatment: A study evaluates the antioxidant properties and therapeutic effects of berberine hydrochloride-loaded liposomes in gel form, potentially analogous to applications for encapsulated forms of Amiodarone-D₄ in dermal pharmaceutical preparations (Shen et al., 2024).

  • Synthetic Routes for Cancer Therapy: A review on the synthetic pathways and clinical applications of small-molecule EGFR inhibitors for cancer treatment provides a framework that can be applied to the development and application of Amiodarone-D₄ hydrochloride in oncological research (Wang et al., 2024).

  • Drug Release Behaviors in Nanoparticles: Investigation into the impact of various factors on the properties of poly(lactic-co-glycolic acid) nanoparticles co-loaded with hydrophilic and hydrophobic drugs, relevant for the formulation of Amiodarone-D₄ hydrochloride for controlled drug delivery systems (Wang et al., 2024).

  • Traditional Chinese Medicine and Sjögren Syndrome: Case report on a rare pattern of primary Sjögren syndrome treated with traditional Chinese medicine, highlighting the diverse therapeutic approaches that could integrate Amiodarone-D₄ hydrochloride in complex treatment regimens (Chen et al., 2024).


法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Cordarone is a registered trademark of Sanofi S.A.
Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

49.5 °F - closed cup

閃點(°C)

9.7 °C - closed cup


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商品

For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods for accurate assessment of drug efficacy. Industrial trends toward highly specific LC/MS applications over traditional immunoassay have resulted in the need for high-speed chromatographic assays along with simplified sample preparation methods.

For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods for accurate assessment of drug efficacy. Industrial trends toward highly specific LC/MS applications over traditional immunoassay have resulted in the need for high-speed chromatographic assays along with simplified sample preparation methods.

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