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880680P

Avanti

C16 PEG750 Ceramide

Avanti Research™ - A Croda Brand 880680P, powder

别名:

N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]}

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About This Item

CAS号:
212116-78-4
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

powder

包裝

pkg of 1 × 25 mg (880680P-25mg)

製造商／商標名

Avanti Research™ - A Croda Brand 880680P

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

O=C(CCC(OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC)=O)OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC.C=C

相关类别

一般說明

Ceramide is a sphingolipid metabolite. The ceramides differ in their acyl chain length.

應用

C16 PEG750 Ceramide might be used as a control to test for nonspecific interactions during titrations of DNA-nanotube complexes with polyethylene glycol (PEG)-conjugated lipids.

生化／生理作用

Therapeutic drugs enclosed in poly-ethylene glycol (PEG) conjugated ceramide serves as liposomal carriers, ensuring a longer circulation period. It exhibits a neutral surface electrostatic charge which prevents the leaking of positively charged encapsulated drug molecule.

包裝

5 mL Amber Glass Screw Cap Vial (880680P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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分析证书(COA)

Lot/Batch Number

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Prakrit V Jena et al.
ACS nano, 11(11), 10689-10703 (2017-09-13)
Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipid flux specifically within the lysosomal lumen of live cells. We developed
M S Webb et al.
Biochimica et biophysica acta, 1372(2), 272-282 (1998-07-24)
Poly(ethylene glycol) (PEG) conjugated lipids have been used to increase the circulation longevity of liposomal carriers encapsulating therapeutic compounds. PEG is typically conjugated to distearoylphosphatidylethanolamine (DSPE) via a carbamate linkage that results in a net negative charge on the phosphate
Jamie L Betker et al.
Journal of pharmaceutical sciences (2020-02-01)
Nanoparticle-mediated drug delivery has long utilized PEGylation as a mechanism for reducing uptake by the reticuloendothelial system and extending circulation lifetimes. However, studies over the past 2 decades have established that immune responses to PEG can promote clearance on repeat injection

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